As a consequence, adding a β-lactamase inhibitor that is commonly used to potentiate treatment against β-lactam-resistant strains can reduce rather than increase treatment efficacy. Together, these results underscore the importance of systematic mapping the long-term clearance efficacy of drug ...
The increase in adverse events associated with taking a combination of a statin drug with one of the other drugs mentioned above is probably due to a drug:drug interaction likely related to the metabolism of most statins also by the same cytochrome P450 isoenzyme 3A4. Therefore when a drug ...
One approach is the systematic high-throughput testing of pairwise drug combinations, which, however, faces a combinatorial challenge: for 1000 U.S. Food and Drug Administration (FDA)-approved drugs, there are 499,500 possible pairwise combinations that should be tested over approximately 3000 huma...
Four null hypotheses were tested: H01 –High light intensity does not increase the long-term toxicity of Li to D. magna; H02 –High light intensity does not increase the long-term toxicity of Li-MPs mixtures to D. magna; H03: Warmer temperature does not increase the long-term toxicity of...
Yogurt is a traditional fermented food that dates back to 6,000 BCE (Weerathilake et al., 2014). Yogurt is made from milk fermentation by a coculture of Streptococcus thermophilus and Lactobacillus delbrueckii ssp. bulgaricus, 2 lactic acid bacteria (LAB) commonly consumed by humans. Protocoope...
Phorate has diverse effects that are herbicide and population dependant in field-selectedL. rigidum, suggesting P450 involvement in the metabolism of trifluralin and failure to activate thiocarbamate herbicides in these populations. This research highlights the need for implementation of diverse ...
Also as weight loss agents acting to decrease food intake such as sibutrimine, CB1 antagonists, 5HT2C agonists, MCHR1 antagonists, and agents that decrease nutrient absorption (such as lipase inhibitors (Orlistat)), and agents that they increase energy expenditure as thymomimetics, or decrease ...
and low-temperature conditions up to 185 days inw1118strain and up to 213 days in long-livedE(z)/wmutants. The trade-off was found between longevity and locomotion. The transcriptome analysis showed an impact of epigenetic alterations, lipid metabolism, cellular respiration, nutrient sensing, imm...
and solutions to increase the number of clinical trials of drug–radiotherapy combinations and to design realistic registration strategies for these combinations. The organizing committee approached all pharma- ceutical and biotechnology companies in a list of con- tacts collated by the Experimental...
2009. BMP-6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nat. Genet. 41(4), 482-487; WO2016098079 and U.S. Pat. No. 8,980,582. Aspects of the invention are as follows, and these aspects (and any un-numbered paragraphs) are combinable with any other ...