combination with capecitabine is currently recommended as a preferred option for second-line treatment according to the PHOEBE study [6]. Despite these achievements, there are still many issues to be addressed in treating HER2+mBC, such as the potential of new drug combinations, feasibility of new...
the construction of a heterogeneous directed biomedical graph consisting of interconnected genes, proteins, and drugs to capture the network characteristics of AD pathology, accounting for the known associations across the expert-led domain-specific AD pathways. Secondly, the biomedical graph is taken as...
Fig. 3(a) shows the structural model framework with SEM on the proposed Public Acceptance of TDM Policies Model. This model is a combination of three theoretical approaches. The first theory is VBN, which assumes that TDM Acceptance will be influenced by one's partiality to the environment (...
(5) "A drivers license valid in one state is valid in any state". --a) (\forall L )[(\exists S1) \text{Valid}(L,S1) \implies (\forall S2) Valid(L,S2)] , This formula accurately says the same thing as the English sentence. It says, for every license, if there is a ...
Chemical agents that cause DNA damage, such as single-strand and double-strand breaks, loss of excision repair, crosslinking, alkali-labile sites, point mutations and structural and numerical chromosomal aberrations. Damage-associated molecular patterns (DAMPs). Intracellular molecules that are hidden fr...
Compared with other types of cancer, targeted therapy of EAC is still lagging behind30. EGFR, HER2 and MET are amplified and overexpressed in a subset of EAC patients, and they can be targeted in patients with EAC14,31,32. They are oncogenic drivers that signal for proliferation and ...
The invention discloses a structural form of a stereo garage and pedestrian overpass combination crossing a road. According to the structure, lifting shafts (7) are positioned at the ends of vehicle passages (3) in a garage, cement floors are adopted in the vehicle passages (3) and parking ...
We also recorded foraging height (when seen) and activity (i.e. calling, flying, perching, foraging, nesting, and flocking) of all individuals44,64,67, which permitted us to directly evaluate whether vegetation structural changes caused by the storm affected bird behavior, such as foraging ...
Increased copy number alterations (CNAs) indicative of chromosomal instability (CIN) have been associated with poor cancer outcome. Here, we study CNAs as potential biomarkers of bevacizumab (BVZ) response in metastatic colorectal cancer (mCRC). We cluster 409 mCRCs in three subclusters characterize...
(i.e., in place of a bill acceptor, in a specified corner or location, etc.). Any such enclosure or structural shape meeting the needs of the logical devices, the device components, and internal and external mounting requirements is within the meaning of the combination device main body ...