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Mechanistic studies revealed that RT/IL-12 increased expression of MHC class II and co-stimulatory molecules CD40 and CD86 on tumor-infiltrating dendritic cells, suggesting an improvement of their antigen presentation activity. RT/IL-12 also significantly reduced accumulation of tumor-infiltrating myeloid...
Bortezomib is a standard treatment for multiple myeloma (MM), working by the accumulation of toxic misfolded proteins in cancer cells. However, a significant clinical challenge arises from the development of r... Authors: Chang-Tze Ricky Yu, Yu-Ting Amber Liao, Chi-Yin Nina Chiang, Jo-Mei...
To the best of our knowledge, the only GSA method developed to analyze longitudinal phenotype is the Pathway Analysis via Regression (PAVR) method proposed by Adewale et al. [7]. This method utilizes regression modelling to analyze binary, multi-class, continuous, count, rate, survival and ...
Notably, the combination of 40 μM quercetin and 3 nM paclitaxel exhibited a significant effect on cell viability for A2780 cells (Figure 1E), with a CI value of 0.62. The optimal synergistic effect for SKOV3 cells (Figure 1F) was achieved through the combination of 15 μM quercetin and...
The size of the cell is 8 × 8 pixels. Histograms of edge gradients with 9 orientations are calculated from each of the local cells. Then the total number of HOG features becomes 576 = 9 × (8 × 8) and they constitute a HOG feature vector. To avoid sudden changes in the descriptor...
which they can present to the immune-surveying T cells. If T cells recognize their specific antigen during communication with macrophages, they will become activated and will be allowed the entry of additional immune cells into the brain [100], nevertheless in the absence of it, T cells were ...
we profiled immune cells in the circulation and in the tumor microenvironment of longitudinal biopsies of metastatic lesions. Besides PD-L1 expression, stromal tumor-infiltrating lymphocyte (sTIL) and CD8+T cell levels, deconvolution algorithms and specific immune-related gene signatures were used to ...
The IL-12 polypeptide has a biological activity of IL-12. A biological activity of IL-12 in the context of the present invention is the stimulation of NK or T cells by said IL-12 polypeptide, most prominently the stimulation of T effector cells acting through perforin. In one embodiment ...