The present disclosure relates to pharmaceutical compositions comprising a therapeutically effective amount of a selective alpha-adrenergic receptor agonist or an anticholinergic agentor a pharmaceutically acceptable salt or a stereoisomer thereof in combination with a therapeutically effective amount of lipoic a...
Cooling is used, as far as it is necessary, to attain complete rigidity and strong connections of the electrons of the conducting material to the surrounding non-conducting material. The chains of atoms of the conducting materials are bonded together to composite units and are enclosed by non-...
Regarding CD-based polymeric nanosystems, many human trials are still ongoing and being initiated to produce advanced results in the field of combination therapy for cancer. Majority ongoing studies, as mentioned previously, involves the combinations of multiple antitumor medications or together with immun...
This compound is the prototype of a series of N-hydroxyimides bearing three oxygen atoms at optimal distances for interaction with the two divalent metal ions (Mg2+) present in the active site of both enzymes. The synthesis of other N-hydroxy imides differently substituted at position 7 or 4...
Pharmaceutical combinations of a CETP inhibitor and atorvastatin or hydroxy metabolites thereof or a pharmaceutically acceptable salt thereof, methods of using such combinations and kits containing such combinations for the treatment of atherosclerosis,
And R or R is an aryl group which may be combined with the nitrogen atom and the carbon to which they are attached an aliphatic group, optionally substituted -H, be substituted independently R -R , and together with the carbon and nitrogen atoms to which they are bonded, R and / or ...
to the carbon atom in the phenyl ring while maintaining R ^2 ^; R 3a 4 and R 3b 4 are independently selected from the group consisting of hydrogen atoms and C 1 -C 4 alkyl groups; X and Y are independently selected from the group consisting of direct bond and hydrogen atom n, meq...
A compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein: Y is a covalent bond, phenylene group or hydrocarbyl group substituted straight-chain or unsubstituted, or Y together with both> C> = Z to which it is bonded, is a substituted or unsubstituted aromatic ...
the heterocyclic ring containing a total of 1, 2 or 3 double bonds inclusive of the bond in the pyridine or pyrimidine ring, with the provisos that the heterocyclic ring does not form part of a purine and that the fused heterocyclic ring does not contain two adjacent O or S(O)m atoms...
For the groups below, the following parenthetical subscripts further define the groups as follows: “(Cn)” defines the exact number (n) of carbon atoms in the group; “(C≤n)” defines the maximum number (n) of carbon atoms that can be in the group; (Cn-n′) defines both the minim...