Concerns regarding drug-drug interactions and overlapping toxicities of antiretroviral agents and chemotherapy agents are now fairly easily managed using newer HIV medications (Table 4). Preferred regimens at our institution have evolved over time; although we initially avoided protease inhibitors and prefer...
Here, we show that zidovudine, a structural analog of thymidine and a potent inhibitor of HIV replication, exhibits similar metabolic patterns to ΔnudB (Figure 7A), and as predicted, a strong synergistic interaction with sulfamethizole (FICi = 0.1) (Figures 7B, 7C, and S7). To test ...
the degree of advancement of the disease; the age, body weight, general health, gender and diet of the individual; the time and route of administration; and other medications the individual is taking. Optimal dosages may be established using routine testing and procedures that are well known in...