Furthermore, both diseases, diabetes and obesity, have been shown to be risk factors for a number of related diseases, including microbial and macrovascular complications and nonalcoholic fatty liver disease (NAFLD)6. Glucagon-like peptide-1 (GLP-1)7 is a natural hormone produced by intestinal ...
Insulin resistance presents a formidable public health challenge that is intricately linked to the onset and progression of various chronic ailments, including diabetes, cardiovascular disease, hypertension, metabolic syndrome, nonalcoholic fatty liver disease, and cancer. Effectively addressing...
Furthermore, both diseases, diabetes and obesity, have been shown to be risk factors for a number of related diseases, including microbial and macrovascular complications and nonalcoholic fatty liver disease (NAFLD)6. Glucagon-like peptide-1 (GLP-1)7 is a natural hormone produced by intestinal ...
Aging is the primary risk factor for diabetes, cancer, heart disease, stroke, and many chronic illnesses. As age increases, fat shifts from subcutaneous areas to abdominal and ectopic sites such as the liver and muscles, with an increase in adipose tissue during middle age followed by a declin...
The molecular chaperone heat shock protein 90 (HSP90) regulates multiple crucial signalling pathways in cancer by driving the maturation of key signalling
Atherosclerosis, with fatty streaks gradually developing into atheroma and characteristic plaques inside the arteries, is the main pathophysiological condition resulting in cardiovascular disease (CVD) [1, 2]. Despite of the emerging pharmacological interventions and lifestyle changes, atherosclerotic cardiovasc...
Instead, it exits the liver, while the LPS associated with it is inactivated. The enzyme acyloxyacyl hydrolase deacylates critical fatty acid residues in LPS for TLR4 activation. It can still access and act on HDL3-associated LPS to detoxify it. This represents a disease-tolerance strategy to...
According to Dr. Imig, "This work is a major step forward in obtaining our goal to develop novel EET analogs for the treatment of cardiovascular disease." He added, "We strongly believe that these EET analogs are therapeutically promising and can be further developed as a novel treatment for...
Many health and social comorbidities, such as cardiovascular disease, type 2 diabetes mellitus, cancer, nonalcoholic fatty liver disease, arthritis, infertility, eating disorders, unemployment, and low quality of life, have been associated with obesity. Nowadays, bariatric surgery is the only effective...
COVID-19, an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread throughout the world. China has achieved rapid containment of this highly infectious disease following the principles of early detection, early quarantine and early treatment with integr...