cell death. In another study, VGF was shown to be induced by optic nerve crush. The VGF peptide, AQEE-30, suppressed the loss of retinal ganglion cells in mice with optic nerve crush and promoted outgrowth of neurites of rat- and human-induced pluripotent stem cells-derived retinal ...
In order to evaluate whether TE-ES models recapitulate the initial steps of tumor generation, necrotic areas in the core of the tumor models were analyzed and compared the levels of HIF1α and GLUT1 to those in cell monolayers and TE-bone controls. First, focus on the construct interiors re...
5. The cell of claim 4, wherein the vector is stably integrated into the genome of the cell. 6. The cell of claim 5, wherein the cell is a neuronal cell or a stem cell. 7. The isolated polynucleotide of claim 1, wherein the regulatory elements comprise a sequence having at least ...
the cell is a peripheral or central nervous system cell or progenitors thereof, including, without limitation, embryonic stem cells, neural stem cells, glial cells, neurons, astrocytes, oligodendrocytes and the like.
Similarly, the core catalytic domains of tyrosine recombinases (e.g., Cre, integrase) are known, and can be similarly co-opted to engineer programmable site-specific recombinases as described herein. In some embodiments, the recombinase comprises Cre recombinase, a mutant, variant or catalytic ...
Sheathing a core of blood with a fluid (sometimes referred to herein as an “extraction fluid” to identify a function thereof), or assuring that the extraction fluid flows between at least a substantial portion of the blood and the enclosing boundaries of the flow path, prevents, or at leas...
The driving force for this rearrangement is the greater thermodynamic stability of the original ginkgolide core. Namely, the bulky tert-butyl group is axial in iso-GC while it is pseudo-equatorial in GC and the 6-membered ring E in iso-GC adopts a boat conformation. Scheme 4. Synthesis of...
Saiki et al., “Biological activities of synthetic polypeptides containing a repetitive core sequence (Arg-Gly-Asp) of cell adhesion molecules,” Int. J. Biol. Macromol. 11: 23-25 (1989). ;. 11: 23-25 (1989). Carey, F.A., Organic Chemistry, McGraw-Hill, New York, pp. 1050-1051...
The dose will vary depending on the specific cytotoxic agent utilized, type of tumor, patient status, etc., at a dose sufficient to substantially ablate the tumor cell population, while maintaining patient viability. In some cases therapy may be combined with stem cell replacement therapy to recon...
or to a peptidic or peptidomimetic region flanking the core domain. Alternatively, the modifying group can be coupled to a side chain of an amino acid residue of the LPL S447X peptide, or to a peptidic or peptido-mimetic region flanking the core domain (e.g., through the epsilon amino ...