and enhanced CDK4 expression,which is tightly associated with the cell cycle and proliferation in cancer cells.Finally,we found that MYC interacted with PTPN18 and increased the protein level of MYC.In conclusion,our results suggest that PTPN18 promotes CRC development by stabilizing the MYC ...
The Evolving Tool Box in Advanced HR+/HER2– Breast Cancer: What You Need to Know About Next-Generation SERDs, PI3K/AKT, ADCs, CDK4/6 and Beyond… View More 18th Annual New York GU Cancers Congress™ March 28-29, 2025 Register Now! Tumor-Infiltrating Lymphocyte Therapy Advances Into Me...
Acquired drug resistance is a major challenge for cancer therapy and is the leading cause of cancer mortality; however, the mechanisms of drug resistance are diverse and the strategy to specifically target drug-resistant cancer cells remains an unmet cli
Colorectal cancer is the third most common death-causing disease in the developed countries. It arises after a series of mutations in various tumor suppressor and proto-oncogenes, each of which are accompanied by specific alterations and pathological conditions. Recent advances have contributed a ...
-mutated colorectal cancer 来自 Nature 喜欢 0 阅读量: 4 摘要: In colorectal cancer, mutation of(RAS) reduces therapeutic options, negatively affecting prognosis of the patients. In this setting, administration of CDK4/6-inhibitors, alone or in combination with other drugs, is being tested as ...
colorectal cancer chemotherapy barcode drug tolerant persisters equipotent diapause slow-cycling MRD autophagy mTOR Introduction There is increasing evidence that non-genetic processes drive drug tolerance, presenting a major hurdle to successful cancer therapy (Recasens and Munoz, 2019). Drug-tolerant persi...
Colorectal cancer : new aspects of molecular biology and immunology and their clinical applications Where you can find the colorectal cancer new aspects of molecular biology and immunology and their clinical applications easily? Is it in the book store? On-line book store? are you sure? Keep in...
Higher frequency of Smad4 inactivation or loss of expression is observed in metastasis of colorectal cancer (CRC) leading to unfavourable survival and contributes to chemoresistance. However, the molecular mechanism of how Smad4 regulates chemosensitivit
colorectal cancer; cyclin D1; p16INK4a; thymidylate synthase High expression of thymidylate synthase (TS) is allegedly associated with the chemoresistance to 5-fluorouracil (5-FU) in colorectal cancers. However, low TS expression does not necessarily imply chemosensitivity. Inactivation of p16INK4a...
Fig. 2. mRNA expression of CDK-1 and CDK-4 in various cancer types. The mRNA expression of CDK-1 and CDK-4 (cancer against normal tissue) was evaluated using the Oncomine (A) and TIMER (B) computational tools. The red color represents significant overexpression whereas blue color represents...