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During intestinal inflammation in several murine models of inflammatory bowel disease (IBD), blood monocytes become largely CD11c−CX3CR1intLy6chiMHCII+inflammatory/effector monocytes, that are thought to play a major role in chronic colitis and IBD through their production of inflammatory cytokines,...
Thus, inhibition of SphK1 represents a means to enhance the therapeutic efficacy of ICD-inducing agents. Keywords: sphingolipids; ceramide; sphingosine phosphate; cell signaling; inflammation; immunogenic cell death; Bak; Bax; colorectal cancer 1. Introduction Sphingosine-1-phosphate (S1P) is a pro...
cxns_per_ctrl = phba->fw_config.iscsi_cid_count; phba->params.asyncpdus_per_ctrl = phba->fw_config.iscsi_cid_count * 2; phba->params.icds_per_ctrl = phba->fw_config.iscsi_icd_count;; phba->params.icds_per_ctrl = phba->fw_config.iscsi_icd_count; phba->params.num_sge_per_io...