Colorectal cancer is one of the most common cancers. In Singapore, colorectal cancer is the most common cancer amongst males, accounting for almost 17% of all cancers in males, and second tobreast cancerin females, making up 13% of all cancers in females1. The good news is that the ...
Yu et al. discovered the role of androgen in proliferation and differentiation of intestinal stem cells, a mechanism that may explain the higher levels of colorectal cancer in males. The dichotomy of androgen action in the gut and its ink in colorectal cancer is illustrated by the...
Sex exerts a profound impact on cancer incidence, spectrum and outcomes, yet the molecular and genetic bases of such sex differences are ill-defined and presumptively ascribed to X-chromosome genes and sex hormones1. Such sex differences are particularly prominent in colorectal cancer (CRC) in whic...
The first by producing several soluble factors involved in carcinogenesis and the second for having a key role in the nutritional and functional decline of patients with cancer. Furthermore, gender differences in relative body composition and adipose tissue regional distribution have also been ...
Abstract The ASMR for cancer of the colon in men was 3.0 in 1963 and 4.6 in 1982, while the respective figures for women were 2.8 and 3.4. The time trend for 1963–1982 was in two phases: an increase in mortality over the period 1963–1978 in males and females, and after that, in...
Some factors related to Westernization or industrialization increase risk of colon cancer. It is believed widely that this increase in risk is related to t
There is a strong association between obesity and colorectal cancer (CRC), especially in men, whereas estrogen protects against both the metabolic syndrome and CRC. Colon is the first organ to respond to high-fat diet (HFD), and estrogen receptor beta (E
Colon cancer is considered one of the common, deleterious disease of the gastrointestinal tract associated with high morbidity and mortality. CRC is ranked among the top three carcinomas of the world behind prostate carcinoma and lung carcinoma (Jemal et al., 2010) .In both males and females, ...
in higher incidence among Blacks than Whites by the mid-1980s and an increasingly greater excess of this cancer in males. Trends toward earlier diagnosis of invasive colon cancer were found, with increasing rates for localized and regional diseases coupled with stable or decreasing distant-stage ...
Sex exerts a profound impact on cancer incidence, spectrum and outcomes, yet the molecular and genetic bases of such sex differences are ill-defined and presumptively ascribed to X-chromosome genes and sex hormones1. Such sex differences are particularly prominent in colorectal cancer (CRC) in whic...