Texas Colon & Rectal Specialists-Baylor Charles A. Sammons Cancer Center 3410 Worth Street, Suite 140 Dallas, TX 75246 T:214-515-5552 Nathaniel Ng, M.D., FACS, FASCRS Roberto Rodriguez-Ruesga, M.D., FACS, FASCRS Texas Colon & Rectal Specialists–Boerne ...
In the stage IV panel, however, overall survival was not significantly different between the methylation and nonmethylation group. Table 1. Multivariate Cox regression analysis of potential prognostic factors for colon cancer patients Variable HR (95% CI) P-value Age 1.038 (0.989–1.090) 0.131 ...
transiently increased SALL2 protein levels in SW480 colon cancer cells (Fig.5F, G, Supplementary Fig.6A) and H1299 human lung cancer cells (Supplementary Fig.6B). Long-term treatment resulted in cell death, as shown by immunodetection of cleaved-PARP (Fig.5D, F). Together, our results su...
Hyperglycemia is a common feature of diabetes mellitus, considered as a risk factor for cancer. However, its direct effects in cancer cell behavior are relatively unexplored. Herein we show that high glucose concentration induces aberrant glycosylation, increased cell proliferation, invasion and tumor pr...
To evaluate the role of CDX2 in the tumor formation ability in vivo, the CDX2-modified colon cancer cells and their control cells were injected subcutaneously into nude mice. The xenograft tumors in CDX2-knockdown group were larger and heavier than those in the control group (Fig.1a, b, ...
We then subjected the tumors to H&E staining and immunohistochemistry. Staining showed that tumor tissues in each group were not presented as colorectal cancer structure (Fig.7d), as these are xenograft mouse models. However, tumor tissues revealed an increase of a homogeneous cell population, inc...
HFBR Loponte1, NR Mantuano1, IA Oliveira1, IF de Paula2, LK Teixeira3, JCM de-Freitas-Junior2, KC Gondim2, N Heise1, R Mohana-Borges1, JA Morgado-Díaz2, WB Dias1 and AR Todeschini1 Hyperglycemia is a common feature of diabetes mellitus, considered as a risk factor for cancer. Ho...
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget. As of January 1, 2022, Oncotarget ...
group in both SW480 and HT-29 cells (Fig. 3F). Cell migration is a crucial process in cancer metastasis (12), thus, a wound-healing assay was employed to assess the migration and invasion of colon tumor cells. High levels of let-7i-5p resulted in a significant decrease in cell ...
Inflammatory bowel disease (IBD) is a complex and multifactorial disorder that includes Crohn’s disease and ulcerative colitis (UC), both characterized by chronic relapsing inflammation and intestinal epithelium damage associated with increasing risk of colorectal cancer1,2,3,4. UC is a major form ...