(intratumoral - invasive front - extratumoral), cell types (tumor cells - macro- (large and small vessels) and the microvasculature (capillaries) - inflammatory cells) in human sporadic non-metastatic, lymphogenous metastatic and haematogenous metastatic CC.VEGF and PlGF produced by tumor cells ...
Validation in an independent cohort of normal colon and patient-derived colon cancer cell lines identified a novel lncRNA, lincDUSP, as a potential candidate oncogene. Knockdown of lincDUSP in patient-derived colon tumor cell lines resulted in significantly decreased cell proliferation and clonogenic...
Accumulating evidence show that myoferlin, a member of the ferlin family, is highly expressed in several cancer types, where it acts as a tumour promoter and participates in the metabolic rewiring towards oxidative metabolism. In this study, we showed that myoferlin expression in colon cancer ...
Cheng H, Leblond CP. (1974) Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian theory of the origin of the four epithelial cell types. Am J Anat 141: 537–561. ArticlePubMedCASGoogle Scholar Ponder BA, Schmidt GH, Wilkins...
All cell types studied so far express several tetraspanins, often to a high level. These molecules have been implicated in a large variety of physiological processes such as immune cell activation, cell migration, cell-cell fusion (including fertilization), and various aspects of cellular ...
Colon cancer is a type of cancer that arises in the colon due to genetic alterations affecting cell growth, differentiation, and death, often influenced by dietary factors like high fat consumption and low intake of fruits and vegetables.
V. Unitarian theory of the origin of the four epithelial cell types. Am J Anat 1974, 141:537–561. Article CAS PubMed Google Scholar Kirkland SC: Clonal origin of columnar, mucous, and endocrine cell lineages in human colorectal epithelium. Cancer 1988, 61:1359–1363. Article CAS PubMed...
To determine if human colon cancer cells remain responsive to the crypt growth factors, we cultured a panel of human colon cancer cell lines (Figure 1C) embedded in 3-D Matrigel in the presence or absence of EGF (E), Wnt3a (W), R-Spondin1 (R) and Noggin (N) (RNEW). Cells grown...
AIM: To analyze the biological effects of prolonged in vitro exposure of HT-29 and LoVo colon cancer cell lines to gefitinib (Iressa TM), an inhibitor of epidermal growth factor receptor (EGFR) activity, and ZD6474, an inhibitor of both KDR and EGFR activities. METHODS: Cells were treated ...
During microevolution in hosts, various cancer cell types with high turnover rates develop mechanisms to escape immunosurveillance26,27,28,29. One approach of cancer therapy is to utilize the immunogenic cancer cell death (ICD) triggering the immune system as defender against tumors. In this concept...