Ion mobility spectrometry (IMS) in combination with mass spectrometry (MS) provides complementary information to m/z, the so-called collision-cross-section (CCS, ? (A~2)),which may be useful for the identification of human and veterinary drugs [1]. So far, only a reduced number of these...
ion mobility can rapidly separate metabolite ions based on their differences in rotationally averaged surface area or collision cross-section (CCS)16,17. It enables to distinguish the isomeric metabolites that commonly exist in biological samples18,19,20,21. Unlike retention time (RT) and MS/MS ...
Metals in Medicine: Collision Cross-Section Comparisons Across Different Travelling-Wave-Based Ion Mobility Instrument Platforms GOAL Ion mobility (IM) combined with mass spectrometry can provide information on the physical size and shape of gas-phase ions, which can assist in the optimization of ...
The investigation of macromolecular biomolecules with ion mobility mass spectrometry (IM-MS) techniques has provided substantial insights into the field of structural biology over the past two decades. An IM-MS workflow applied to a given target analyte provides mass, charge, and conformation, and al...
This application brief determines the collision cross-sections of singly charged lipid ions analyzed by MALDI mass spectrometry. Benefits The MALD I SYNA PT G2 HDMS System provides an ideal platform to conduct lipid imaging studies, and in addition, allows the coll...
fast-responsedetector thatcanoperateatthesepressures.Thisinstrument allowssimultaneousdeterminationofmassandcollision crosssectionsoftheionswiththebathgas.Herewe demonstratetheLVMS’sabilitiestodeterminetotalcol- lisioncrosssectionsforthecollisionsoforganicionswith threebackgroundgases,He,N 2 ,andSF 6 .Asademon- ...
Learn about the fundamentals of ion mobility mass spectrometry (IMS) and the benefits of collisional-cross section (CCS) data.download video Learn more Share: Share What are ion mobility MS and collision cross section data? on Facebook Share What are ion mobility MS...
The collision cross section (CCS) values derived from ion mobility spectrometry can be used to improve the accuracy of compound identification. Here, we have developed the Structure included graph merging with adduct method for CCS prediction (SigmaCCS) based on graph neural networks using 3D confor...
Collision cross section (CCS) is a robust and precise physicochemical property of an ion. CCS is an important distinguishing characteristic of an ion that is related to its chemical structure and three-dimensional conformation, illustrated in Figure 1, where...
1 LipidCCS:PredictionofCollisionCross-SectionValuesfor LipidswithHighPrecisiontoSupportIonMobility-Mass SpectrometrybasedLipidomics ZhiweiZhou 1,2 ,JiaTu 1,2 ,XinXiong 1 ,XiaotaoShen 1,2 ,andZheng-JiangZhu 1, * 1 InterdisciplinaryResearchCenteronBiologyandChemistry,andShanghaiInstituteof OrganicChemistry...