Type IX collagenHemocytesBased on previous cloning and sequencing study, real-time PCR and in situ hybridization assays of the inflamed body wall of LPS-injected Ciona intestinalis showed the enhanced gene expression of a collagen with FACIT structural features ( Ci-type IX-Col 1 伪-chain). By...
(A) Four structures (121nat, 121sm, 111sm and 211sm) are superimposed within the NC2 domain core. Cα-positions of residues 33–39 are shown as spheres. (B) Inter-chain hydrogen bond lengths within the triple-helix and the interface. Chain A (α1 of NC2) – magenta, chain B (α...
The amino acid sequence determines how the peptide folds, mainly in a left-handed alpha-helix. The hydrogen bonding between the amino acid residues forms a stable spatial structure, and the three levorotatory alpha-helices of the peptide chain form a tertiary structure through condensation reactions...
The worm﹍ike chain (WLC) model [4] with its approximation [6] is a widely used approach for the modeling of DNA, which has a helical structure similar to tropocollagen. However, the classical WLC is suitable only for the entropic deformation regime of collagen. By modeling the extension ...
et al. Collagen IX is indispensable for timely maturation of cartilage during fracture repair in mice. Matrix Biol. 26, 85–95 (2007). CAS Google Scholar Fässler, R. et al. Mice lacking alpha 1 (IX) collagen develop noninflammatory degenerative joint disease. Proc. Natl Acad. Sci. ...
Usage of the short form of the alpha1(IX) chain in bovine nucleus pulposus. J Biol Chem 278:24521–24525 Article PubMed CAS Google Scholar Wu JJ, Eyre DR, Slayter HS (1987) Type VI collagen of the intervertebral disc. Biochemical and electron- microscopic characterization of the native ...
COLI fibers exhibited covalent crosslinking with prolyl 4-hydroxylase alpha 1 and prolyl 4-hydroxylase alpha 2 in differentiated cell types of triple-negative breast cancer, and the prolyl 4-hydroxylase alpha 1/HIF-1 axis increased chemoresistance [112, 113]. Even mutant p53 regulated the ...
In contrast, the NC1-laminin 5 interaction was not affected by a monoclonal antibody to the alpha3 chain. Using NC1 deletion mutant recombinant proteins, a 285 AA (residues 760-1045) subdomain of NC1 was identified as the binding site for laminin 5. IgG from an epidermolysis bullosa ...
Facit collagens (fibril-associated collagen with interrupted triple helix): types IX, XII, XIV • Short-chain collagens: types VIII, X • Basement membrane collagens: type IV • Other collagens: types VI, VII, XIII. Collagen types I, II and III are arranged as rope-like fibrils and...
The skeleton of type II collagen molecule is the collagen triple helix, and each alpha-chain helical region is composed of 1014 amino acids with glycine occupying every third position (Gly-X-Y), which is critical to the helix folding and stability [6,12]. Type II collagen is characterized ...