The plug-in cytoHubba was applied to identify hub genes based on degree(28). The intersections of the hub genes obtained by CytoHubba were considered as potential anti-inflammatory drug targets.Establishment of inflammation mouse model and treatment protocol All animal studies were conducted with ...
Medical Encyclopedia Wikipedia </>embed</> painkiller pain pill anodyne analgesic colchicine noun Words related to colchicine nounan analgesic drug derived from the saffron plant and used to treat gout Related Words analgesic anodyne pain pill
7. Drug Interactions Colchicine is a substrate of the efflux transporter P-glycoprotein (P-gp), and the CYP3A4 metabolizing enzyme. Fatal drug interactions have been reported when colchicine is administered with clarithromycin, a dual inhibitor of CYP3A4 and P-glycoprotein. Toxicities have also be...
Adherence to colchicine is one of the main factors affecting colchicine response. In this study, we aimed to evaluate drug adherence in children with FMF using the medication adherence scale in FMF (MASIF). We also assessed the clinical characteristics of drug-adherent...
Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as Colchicum autumnale, or "autumn crocus."4 Its use was first approved by the FDA in 1961.11 Colchicine is used in the treatment of gout flares and Familial Mediterranean fever,9 and prevention of majo...
Biphasic kinetics of Colchicines-tubulin interaction has been explained in light of the variation in the residues around the drug-binding site on beta-tubulin. Using the crystal structure of the tubulin-DAMAColchicine complex, a detailed discussion on the pharmacophore concept that explains the ...
The drug candidate potency depends not only on its cytotoxicity in malignant cells, but also on its relative lack of toxicity toward normal cells. Therefore, we evaluated the effects of compound 5b, 5f and 5k on human fetal hepatocyte line L02 (non-cancer cell line) by MTT assay. As shown...
The cytotoxic drug colchicine when administered to mice in conjunction with Ag was shown to have a strong adjuvant effect in generating a specific plaque-forming cell response to the protein Ag OVA, human gamma-globulin and BSA. Dissection of this phenomenon revealed that several T cell activities...
Acute kidney injury (AKI) is a major health problem affecting millions of patients globally. There is no effective treatment for AKI and new therapies are urgently needed. Novel drug development, testing and progression to clinical trials is overwhelming
As anti-inflammatory drugs such as acetylsalicylic acid are known to partially restore insulin response to glucose, the possible beneficial effect of colchicine, an anti-gout and anti-inflammatory drug, in non-insulin dependent diabetes mellitus (NIDDM) was studied. Colchicine could significantly reduce...