In this study, the mechanism that might explain the positive effect of colchicine was inhibition of neutrophil function, a well-known factor in plaque instability. Colchicine effects on the ischaemic myocardium
Searches encompassed colchicine mechanisms of action and clinical applications in medical conditions. A total of 381 articles were reviewed. Results The primary mechanism of action of colchicine is tubulin disruption. This leads to subsequent down regulation of multiple inflammatory pathways and modulation ...
mechanism of actionmolecular dockingnetwork pharmacologyObjective: This is the first study to explore the mechanism of colchicine in treating coronary artery disease using network pharmacology and molecular docking technology, aiming to predict the key targets and main approaches of colchicine in treating ...
However, it's believed the mechanism of action (MOA) of colchicine is to reduce the inflammatory reaction to urate crystals by interfering with a process in white blood cells that triggers inflammation and prevents their migration to areas of inflammation. Colchicine does not affect uric acid ...
In this review we briefly present the biochemical characteristics, mechanism of action and side-effects of colchicine, as well as examine what is currently known about the promising role of colchicine in cardiovascular medicine beyond pericardial disease....
How does colchicine work (mechanism of action)? Neutrophils are a type of white blood cell that play a big role in inflammation. They are involved in inflammation in gout, FMF, and coronary artery disease. Colchicine may block neutrophil activity to reduce or prevent inflammation in all of the...
Indications and Common Uses In 2009, FDA approved Colcrys (single-ingredient colchicine tablet) for three conditions: (1) Familial Mediterranean fever, (2) acute gout, and (3) prophylaxis of gout flares (DHHS, 2010, p. 60768). Mechanism of Action (MOA) The therapeutic efficacy of colchicine...
We also systematically discuss the mechanisms of colchicine action in cardiovascular therapeutics. Altogether, colchicine, a bioactive constituent from an ancient medicinal herb, exerts unique anti-inflammatory effects and prominent cardiovascular actions, and will charter a new page in cardiovascular medicine...
12.1 Mechanism of Action Colchicine’s effectiveness as a treatment for gout has been postulated to be due to its ability to block neutrophil-mediated inflammatory responses induced by monosodium urate crystals in synovial fluid. Colchicine disrupts the polymerization of β-tubulin into microtubules, the...
Colchicine has a good efficacy in treating acute gout and can quickly relieve pain and can prevent the onset of arthritis with its mechanism of action related to the inhibition of white blood cells and proliferation activities and the effect on lysosomal release. ...