1. How it worksColchicine is a medicine that is used to relieve the symptoms of gout. It is thought to work by blocking how our immune system responds to the presence of urate crystals in synovial fluid (the fluid between our joints). Colchicine may also reduce the effect of other ...
Colchicine causes drug interactions when taken along with certain medications, vitamins, or herbs. A drug interaction happens when any kind of substance changes the way the medicine should ideally work. Such changes can cause certain harmful side effects. Thus, to avoid drug interactions, list down...
How does colchicine work (mechanism of action)? Neutrophils are a type of white blood cell that play a big role in inflammation. They are involved in inflammation in gout, FMF, and coronary artery disease. Colchicine may block neutrophil activity to reduce or prevent inflammation in all of the...
DOES COLCHICINE WORK? THE RESULTS OF THE FIRST CONTROLLED STUDY IN ACUTE GOUT We have performed the first controlled study of colchicine in acute gout, to determine its efficacy and toxicity, and to define the natural history of acut... M.,J.,AHERN,... - 《Australian & New Zealand ...
DOES COLCHICINE WORK? THE RESULTS OF THE FIRST CONTROLLED STUDY IN ACUTE GOUT 1987, Australian and New Zealand Journal of Medicine View all citing articles on Scopus1 From the Department of Medicine, Jewish Hospital and Medical Center of Brooklyn, Brooklyn, N.Y., and the Department of Medicine...
Ahern MJ, Reid C, Gordon TP, et al.: Does colchicine work? The results of the first controlled study in acute gout. Aust N Z J Med 1987, 17:301–304. PubMed CAS Google Scholar Jayaprakash V, Ansell G, Galler D: Colchicine overdosage: the devil is in the detail. NZ Med J 200...
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Colchicineis aColchicum autumnaleplant alkaloid that inhibits polymerization of microtubules, a process that is believed to be required for collagen secretion. Thus, this compound is believed to work as an antifibrotic compound by preventing collagen secretion and deposition. Colchicine effectively inhibits...
Colchicine can cause myelosuppression, and therefore, its use requires caution with patients with dental disease. The recommendation is that the dental work is performed before initiating therapy with colchicine or delayed until blood count returned to normal. ...
Our work shows that the efficacy and safety of colchicine depend on its selective action on hepatocytes, and reveals a new axis of liver–myeloid cell communication. Plasma GDF15 levels and myeloid cell SHP-1 activity may be useful pharmacodynamic biomarkers of colchicine action. This is a ...