在Col2a1基因stop codon之前定点敲入2A-CreERT2表达框,建立Col2a1-CreERT2重组酶工具小鼠。该品系繁育无法获得纯合子,建议使用杂合子进行研究。 应用领域:软骨Cre工具鼠 *使用本品系发表的文献需注明: Col2a1-2A-CreERT2 mice (Cat. NO. NM-KI-18029) were purchased from Shanghai Model Organisms Center,...
在Col2a1基因stop codon之前定点敲入2A-CreERT2表达框,建立Col2a1-CreERT2重组酶工具小鼠。该品系繁育无法获得纯合子,建议使用杂合子进行研究。 应用领域:软骨Cre工具鼠 *使用本品系发表的文献需注明: Col2a1-2A-CreERT2 mice (Cat. NO. NM-KI-18029) were purchased from Shanghai Model Organisms Center,...
Two-week-old Col2a1-CreERT2;R26R mice were administered TM for 5 days and were sacrificed 1 and 6 months after TM induction. X-Gal staining was performed. Results Efficient Cre-recombination is achieved in adult articular chondrocytes 1 and 6 months after TM induction. Conclusion Our ...
In vivo MicroRNA-1 attenuates COL2A1-CRE-ERT2; GFPFL/FL-RFP-MIR-1 mice undergo surgery-induced osteoarthritis by down-regulating indian hedgehogdoi:10.1016/j.joca.2020.02.495P. LiX. CheElsevier BVOsteoarthritis and Cartilage
osteoarthritismiR-1Indian hedgehogtransgenic miceThe present study assessed the effects of microRNA?1 (miR?1) on the development of osteoarthritis using human tissues and a Col2a1?Cre?ERT2/GFPfl/fl?RFP?miR?1 mouse model of osteoarthritis. Human cartilage tissues (n=20...
Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-Cre ERT2;Ihhfl/fl mice. Zhou J,Chen Q,Lanske B,Fleming BC,Terek R,Wei X,Zhang G,Wang S,Li K,Wei L. Arthritis Research and Therapy . 2014...