在Col2a1基因stop codon之前定点敲入2A-CreERT2表达框,建立Col2a1-CreERT2重组酶工具小鼠。该品系繁育无法获得纯合子,建议使用杂合子进行研究。 应用领域:软骨Cre工具鼠 *使用本品系发表的文献需注明: Col2a1-2A-CreERT2 mice (Cat. NO. NM-KI-18029) were purchased from Shanghai Model Organisms Center,...
在Col2a1基因stop codon之前定点敲入2A-CreERT2表达框,建立Col2a1-CreERT2重组酶工具小鼠。该品系繁育无法获得纯合子,建议使用杂合子进行研究。 应用领域:软骨Cre工具鼠 *使用本品系发表的文献需注明: Col2a1-2A-CreERT2 mice (Cat. NO. NM-KI-18029) were purchased from Shanghai Model Organisms Center,...
采用小鼠Col2a-1(前胶原II型,α1)启动子序列、β-珠蛋白内含子、Cre-ERT融合基因(Cre重组酶融合到人类雌激素受体(ER)的突变配体结合域)、SV40 pA信号和Col2a-1内含子1增强子构建载体。该转基因被注射到FVB/N受精卵中,随后将其培养到FVB/N以产生半合子。该转基因小鼠对软骨系(软骨)细胞具有很强的他莫西芬...
Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreERT2; Ihhfl/fl mice. Arthritis Res Ther 2014;16:R11.Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-...
Two-week-old Col2a1-CreERT2;R26R mice were administered TM for 5 days and were sacrificed 1 and 6 months after TM induction. X-Gal staining was performed. Results Efficient Cre-recombination is achieved in adult articular chondrocytes 1 and 6 months after TM induction. Conclusion Our ...
In vivo MicroRNA-1 attenuates COL2A1-CRE-ERT2; GFPFL/FL-RFP-MIR-1 mice undergo surgery-induced osteoarthritis by down-regulating indian hedgehogdoi:10.1016/j.joca.2020.02.495P. LiX. CheElsevier BVOsteoarthritis and Cartilage
Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreERT2; Ihhfl/fl mice. Arthritis Res Ther. 2014;16(1):R11.Zhou J, Chen Q, Lanske B, et al. Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically...
osteoarthritismiR-1Indian hedgehogtransgenic miceThe present study assessed the effects of microRNA?1 (miR?1) on the development of osteoarthritis using human tissues and a Col2a1?Cre?ERT2/GFPfl/fl?RFP?miR?1 mouse model of osteoarthritis. Human cartilage tissues (n=20) were collected for ...
品系名:C57BL/6Smoc-Mettl3em1Smoc 品系状态:活体 | 目录号:NM-KO-231191 Mettl3-Flox/Cdh5-2A-CreERT2 品系名:C57BL/6Smoc-Mettl3em1(flox)Cdh5em1(2A-CreERT2-WPRE-polyA)Smoc 品系状态:活体 | 目录号:NM-CKO-233291 你也可能感兴趣