Use the free IDT Codon Optimization Tool to simplify designing synthetic genes and single-stranded or double-stranded DNA fragments for expression in a variety of organisms.
As a leading provider of synthetic DNA, GenScript is dedicated to using the latest advancements to update existing algorithms for improving gene expression. Our most recent development isGenSmart™ Codon Optimization; a free, user-friendly online tool that enables you to optimize the design of wi...
As a leading provider of synthetic DNA, GenScript is dedicated to using the latest advancements to update existing algorithms for improving gene expression. Our most recent development isGenSmart™ Codon Optimization; a free, user-friendly online tool that enables you to optimize the design of wi...
Codon optimization, for which you can use a codon optimization tool, can be used to introduce synonymous mutations that will favor efficient soluble functional protein expression. Codon Bias In protein expression, the synonymous mutations described above may not actually be neutral, because certain ...
The development of human induced pluripotent stem cell (iPSC) technology has revolutionized the regenerative medicine field. This technology provides a powerful tool for disease modeling and drug screening approaches. To circumvent the risk of random int
To quantify those differences and their significance, we used a distribution-free two-sample permutation test with the L1 distance between KDEs serving as the test statistic and assigned p-values to each synonymous codon pair with respect to the null hypothesis that the two codons have the same...
Considering that there is no one-fits-all index for all species, a comprehensive platform supporting the calculation and analysis of multiple CUB indices for codon optimization is greatly needed. Results: Here, we release GenRCA, an updated version of our previous Rare Codon Analysis Tool, as a...
Fuglsang A: Codon optimizer: a freeware tool for codon optimization. Protein Expr Purif. 2003, 31 (2): 247-249. 10.1016/S1046-5928(03)00213-4. Article CAS Google Scholar Grote A, Hiller K, Scheer M, Münch R, Nörtemann B, Hempel DC, Jahn D: JCat: a novel tool to adapt codo...
GenSmart Optimization is a free online tool for performing codon optimization to improve gene expression. GenScript’s patented algorithms are integrated into the tool to optimize the computing capability of high-performance sequence generation.
5. COOL (http://cool.syncti.org/setup_input_sequence_create_wf1.php?=Start+Using+Codon+Optimization+On-Line+%3E %3E %3E) The standard human genetic code was used for all tools. For tools 1˜4 above, one sequence was generated from each tool. For tool 5, default settings were used...