cmaniRa-l3so4 rdeigreucltaltye Snail expression [144,161,162], a regulatory mechanism that has indeed been described in both normal tissue homeostasis [161,162] and pathologic contexts such as ovarian cancer [162]. miR-34 directly targets Snail 3′ untranslated region (UTR), leading to ...
3. Results 3.1. Transgenic FLAG:AGO4 Functions Like Endogenous AGO4 In order to identify the population of RNAs associated with AGO4, a FLAG:AGO4 transgene, driven by the cauliflower mosaic virus 35S promoter, was transformed into ago4-1 (A. thaliana ecotype Landsberg erecta or Ler) mutant...
Etoposide (VP16) and camptothecin (CPT), which induce DNA damage in cancer cells and result in apoptosis, are commonly used in the clinic as chemotherapeutic agents [3,4]. However, DNA repair systems in most HCC cells are abnormally active due to the accumulation of mutations, resulting in ...