These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention and monitoring.doi:EP2543739 A1SJOBLOM TobiasJONES SianPARSONS D. WilliamsWOOD Laura D.LIN JimmyBARBER ThomasMANDELKER Diana...
Serial circulating tumour DNA analysis for locally advanced rectal cancer treated with preoperative therapy: prediction of pathological response and postoperative recurrence The consensus coding sequences of human breast and colorectal cancers. Science. 2006;314:268–74.Sjoblom T, Jones S, Wood LD, Pars...
‘winner’s curse’32. Thus, further replication in larger datasets will also be necessary to provide more precise estimates for variants in the new genes, to define the set of variants in these genes associated with breast cancer, the clinic-pathological characteristics of tumors in variant ...
proliferation, and apoptosis is critical for the normal development and homeostasis of breast cells. The premalignant stages change this balance and the regulatory biomarkers of the
Florida Rep. Debbie Wasserman Schultz, a breast cancer survivor, is part of a bipartisan effort to reverse the coding change. "You know, first you face down whether you're going to survive breast cancer, but psychologically, so much of the aftermath as you go through the process...
What advice are oncologists and surgeons in the United Kingdom giving to breast cancer patients about physical activity? Int J Behav Nutr Phys Act 2008;... AJ Daley,SJ Bowden,DW Rea,... - 《Int J Behav Nutr Phys Act》 被引量: 60发表: 2008年 ICD 10: "What Orthopedic Surgeons Should...
breast cancer cells [120]. On the other hands, synthetic siRNAs has been also used as therapeutic tools inducing ncRNA degradation. For example, a siRNA-mediated HOTAIR degradation suggested a therapeutic role of HOTAIR inhibition, since its negative regulation reduced tumor cells dissemination in ...
Recently several examples of functional lncRNAs transcribed from cancer risk loci have been reported. For example, SNP A 100 80 60 56% 53% 40 42% 40% 25% 22% 20 13% 10% 8% 0 1% 1% BreastThyroidProstateOvarTiaensticulaCr ervical CoPloanncreatic LLuenugkaemiSatomach Type of cancer B ...
Dysregulation of ncRNA interactions within cancer molecular pathways contributes to cancer and reveals important new targets for intervention. In cancer, disruptions in ncRNA networks often do not involve just mutations that cause a gross gain-of-function or loss-of-function of a given ncRNA but can...
MEG3 is downregulated and acts as a tumor suppressor in various cancer types including breast cancer, liver cancer, glioma cancer, colorectal cancer, cervical cancer, gastric cancer, lung cancer, ovarian cancer, and osteosarcoma16,17. For instance, MEG3 has been shown to inhibit cells ...