在基因组学研究中,编码序列(Coding Sequence, CDS)是解析基因功能的核心单元。它直接对应蛋白质的氨基酸序列,是DNA中真正参与编码生命活动的“有效信息段”。本文将系统解析CDS的定义、生物学意义及其在科研与实际应用中的价值。 CDS:从DNA到蛋白质的精准映射 CDS是DNA中能够被转录为...
Here, we have adopted cross-species capture to obtain data for 809 nuclear coding DNA sequences (CDS) in a non-model organism, the Eurasian lynx Lynx lynx, using baits designed with the help of the published genome of a related model organism (the domestic cat Felis catus). In this ...
Particular strengths are: extract protein-coding DNA sequences just as easily as amino acid sequences, full access to taxonomy for labeling and filtering, awareness of incomplete sequences, and the ability to take one protein sequence and extract all synonymous CDS or identical protein sequences ...
the DNA damage sensor ATM phosphorylates MDM2 at Ser395. This induces a conformational change in the protein and favors its interaction with a specific sequence within the CDS ofp53mRNA. Because of this interaction, MDM2 switches from a negative to a positive regulator of p53: it cannot function...
Noun1.coding DNA- sequence of a gene's DNA that transcribes into protein structures; "exons are interspersed with introns" exon deoxyribonucleic acid,desoxyribonucleic acid,DNA- (biochemistry) a long linear polymer found in the nucleus of a cell and formed from nucleotides and shaped like a do...
Further experiments in maize with transgenes individually expressing three crystal (Cry) proteins from Bacillus thuringiensis (Bt) tested the impact of CDS recoding using different codon bias tables. Transgenes with higher GC content exhibited increased transcript and protein accumulation. These results ...
As expected, cell-cycle and p53 DE-TARs were found to be strongly enriched for known protein-coding RNAs (Figure2A, Additional file1: Figure S10). Although STAT3 is known to regulate the expression of many mRNAs, STAT3 DE-TARs were not enriched for coding sequence (CDS) and 5′UTRs and...
(a) Breakdown of sites under selection between coding (CDS) and noncoding regions (left) and among different types of noncoding regions (right). (b) Percentage of sites under selection for different sets of regions of theA. thalianagenome. Noncoding region categories include UTRs: 5′ (blue...
(A) NAME/KEY: CDS (B) LOCATION: 8..1207 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1: TGGGACCATGGCCTCGGAGAAGCCGCTGGCGGCAGTCACTTGTACAGCG49 MetAlaSerGluLysProLeuAlaAlaValThrCysThrAla 1510 CCGGTCAACATCGCGGTCATCAAGTACTGGGGCAAGCGCGATGAAGAG97 ProValAsnIleAlaValIleLysTyrTrpGlyLysArgAspGluGlu ...
“set union” parameter. The GTF files were then processed using Mikado, with two key customisations: 1) a custom parameter file that allowed mono-exonic isoforms to be classified as splice variants; and 2) a custom scoring file that excluded coding DNA sequences (CDS), ensuring that non...