在基因组学研究中,编码序列(Coding Sequence, CDS)是解析基因功能的核心单元。它直接对应蛋白质的氨基酸序列,是DNA中真正参与编码生命活动的“有效信息段”。本文将系统解析CDS的定义、生物学意义及其在科研与实际应用中的价值。 CDS:从DNA到蛋白质的精准映射 CDS是DNA中能够被转录为成熟m...
Coding sequenceGene expressionSaccharomyces cerevisiaeIt is well-established that non-random patterns in coding DNA sequence (CDS) features can be partially explained by translational selection. Recent extensions of microarray and proteomic expression data have stimulated many genome-wide investigations of ...
(A) NAME/KEY: CDS (B) LOCATION: 8..1207 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1: TGGGACCATGGCCTCGGAGAAGCCGCTGGCGGCAGTCACTTGTACAGCG49 MetAlaSerGluLysProLeuAlaAlaValThrCysThrAla 1510 CCGGTCAACATCGCGGTCATCAAGTACTGGGGCAAGCGCGATGAAGAG97 ProValAsnIleAlaValIleLysTyrTrpGlyLysArgAspGluGlu ...
(a) Breakdown of sites under selection between coding (CDS) and noncoding regions (left) and among different types of noncoding regions (right). (b) Percentage of sites under selection for different sets of regions of theA. thalianagenome. Noncoding region categories include UTRs: 5′ (blue...
Further experiments in maize with transgenes individually expressing three crystal (Cry) proteins from Bacillus thuringiensis (Bt) tested the impact of CDS recoding using different codon bias tables. Transgenes with higher GC content exhibited increased transcript and protein accumulation. These results ...
“set union” parameter. The GTF files were then processed using Mikado, with two key customisations: 1) a custom parameter file that allowed mono-exonic isoforms to be classified as splice variants; and 2) a custom scoring file that excluded coding DNA sequences (CDS), ensuring that non...
We conclude that the likelihood of adenosine being methylated depends on the DRACN 5-mer and its distance to the nearest splice site; however, once the modification is made, the RNA is primed for destabilization regardless of that sequence. CDS m6A sites have the strongest effect on transcript...
Noun1.coding DNA- sequence of a gene's DNA that transcribes into protein structures; "exons are interspersed with introns" exon deoxyribonucleic acid,desoxyribonucleic acid,DNA- (biochemistry) a long linear polymer found in the nucleus of a cell and formed from nucleotides and shaped like a do...
The portion of DNA that codes for transcription of messenger RNA. See:exon Medical Dictionary for the Health Professions and Nursing © Farlex 2012 coding sequence (CDS) a genome sequence bounded by a start and stop codon that encodes theAMINO ACIDSof a protein. ...
We call exapted those TE fragments that became a part of a coding sequence (CDS) but do not code for a protein domain attributed to their original function. In humans Alu sequences are major donators of exons, but exons acquired from other elements, such as LINEs, endogenous retroviruses, ...