Cocaine, a derivative of the coca plant, is another commonly used illicit drug with adverse cardiovascular effects. Cocaine is legitimately utilized in some minor medical procedures, such as achieving hemostasis in ENT and nasal surgeries. As an illegal substance, cocaine is either ingested, insuffla...
(countable) Any derivative of cocaine. Chocolate Made or flavored with chocolate Chocolate pudding. Cocaine A powerful narcotic alkaloid, C17H21NO4, obtained from the leaves of coca. It is a bitter, white, crystalline substance, and is remarkable for producing local insensibility to pain. It is...
We have branded cocaine cut with Fentanyl “The New Cocaine”. And in a twist of irony, this new feel-good drug is a highly efficient killer. The 2X increase in cocaine deaths reported by the CDC since 2015 have largely been fueled by this new derivative. “New Cocaine” addicts more qu...
Cocaine N-demethylation by microsomal cytochrome P-450 (CYP) is the principal pathway in cocaine bioactivation and hepatoxicity =-=(32)-=-. Because 123 I-FP-CIT is a cocaine derivative, N-demethylation of FP-CIT will also take place in humans, and after N-demethylation an 123 I-labeled ...
Sustained decrease in cocaine-maintained responding in rhesus monkeys with 1-[2-[bis(4-fluorophenyl)- methoxy]ethyl]-4-(3-hydroxy-3-phenylpropyl) piperazinyl de- canoate, a long-acting ester derivative of GBR 12909. J Med Chem 39: 4689–4691. Grabowski J, Shearer J, Merrill J, Negus ...
Cocaine addiction is characterized by dysfunction in reward-related brain circuits, leading to maladaptive motivation to seek and take the drug. There are currently no clinically available pharmacotherapies to treat cocaine addiction. Through a broad screen of innate immune mediators, we identify granulo...
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a... Question: What is the most popular drug on high-school and college campuses in the United States? a. Marijuana. b. Alcohol. c. Cocaine. d. Heroin. Psychoactive Drugs: The term psychoactive can be used to refer to any dru...
The subject of his prophecy was a substance many in his audience of senior British police officers had not heard of, a highly addictive cocaine derivative called "crack". Mr Stutman warned that these small, off-white crystals would soon be wreaking havoc in British cities, tearing the hearts...
Sustained decrease in cocaine-maintained responding in rhesus monkeys with 1-[2-[bis(4-fluorophenyl) methoxy]ethyl]-4-(3-hydroxy-3-phenylpropyl) piperazinyl decan- oate, a long-acting ester derivative of GBR 12909. J Med Chem 39: 4689–4691. Gorelick DA, Gardner EL, Xi ZX (2004). ...