Cocaethylene: A Unique Cocaine Metabolite Displays High Affinity for the Dopamine TransporterCocaineCNSMonoamine uptake sitesEthanolConcurrent cocaine and alcohol use is common practice in the general population, as indicated by recent prevalence studies. In the presence of ethyl alcohol, cocaine is ...
Alcohol Drug Driving 3:9–12 Google Scholar Clouet D, Asghar K, Brown R (eds) (1988) Mechanisms of cocaine abuse and toxicity. Department of Health and Human Services, National Institute on Drug Abuse research monograph nr 88. Rockville, MD Google Scholar Cone EJ (1995) Pharmacokinetics ...
Beitner-Johnson D, Guitart X, Nestler EJ (1992a) Common intracellular actions of chronic morphine and cocaine in dopaminergic brain reward regions. In: Kalivas PW, Samson HH (eds) The neurobiology of drug and alcohol addiction. New York Academy of Sciences, New York, pp 70–87 Google Scho...
Background Cocaine and ethanol are two most commonly used recreational drugs in United States. Animal studies have shown that combining cocaine and alcohol pro duces a cardiotoxic metabolite known as cocaethylene, which is more arrhythmogenic than either of them alone. The effect of this metabolite...
Alcohol use disorder (AUD) is one of the foremost public health problems. Alcohol is also frequently co-abused with cocaine. There is a huge unmet need for the treatment of AUD and/or cocaine co-abuse. We recently demonstrated that skin grafts generated
Of 420 cocaine-dependent full-sibling pairs (n = 840) who participated in a Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA) interview, 273 (65%) reported cocaine-induced paranoia (34C). Factors associated with sibling cocaine-induced paranoia were analysed by logistic ...
More recently, cocaine augmented with fentanyl has become a common street variety—Psychemedics calls this “New Cocaine” and is directly responsible for the significant increase in deaths by cocaine overdose.AnalyteBenzoylecgonine — Main metabolite of cocaine Cocaethylene — Produced when alcohol and ...
Johnson BA, Roache JD, Ait-Daoud N, Javors MA, Harrison JM, Elkashef A, et al. A preliminary randomized, double-blind, placebo-controlled study of safety and efficacy of ondansetron in the treatment of cocaine dependence. Drug Alcohol Depend. 2006;84:256–63. ...
Effects of Cocaine and Alcohol Alone and in Combination on Cardiovascular Performance in Dogs With the proliferation of cocaine abuse, increased incidence of catastrophic cardiovascular events such as angina pectoris, myocardial infarction, ventricu... MC Mehta,AC Jain,M Billie - 《American Journal of...
Additionally, the esterase also metabolizes cocaethylene, a potent metabolite of cocaine and alcohol, almost as efficiently as it metabolizes cocaine (kcat = 9.4 s-1 and Km = 1600 nM) (Turner et al. (2002) Biochemistry 41, 12297-12307; Larsen et al. (2002) Nature Structural Biology 9,...