17βHSD2 is a microsomaloxidasethat uses NAD+ to inactivate both estradiol to estrone and testosterone to Δ4androstenedione. 17βHSD2 is found in the placenta, liver,small intestine, prostate, secretoryendometrium, and ovary. In contrast to 17βHSD1, which is found in placentalsyncytiotr...
In contrast to 17βHSD1, which is found in placental syncytiotrophoblast cells, 17βHSD2 is expressed in endothelial cells of placental intravillous vessels, consistent with its apparent role in defending the fetal circulation from transplacental passage of maternal estradiol or testosterone.9,30-...
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