Abstract Background Lack of nutrients, in particular nitrogen and phosphorus, has been known in the field to sense glutamate production via 2-oxoglutarate and subsequently accelerate carbon storage, including glycogen and polyhydroxybutyrate (PHB), in cyanobacteria, but a few studies have focused on ...
namely bicalutamide (first generation ARI), apalutamide and enzalutamide (second generation ARI). When compared to parental LNCaP cells, ARI-resistant cells were larger, and exhibited enhanced cell–cell contact.
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Submission: S.L.F. Data availability statement Raw RNA sequencing data have been deposited in ArrayExpress under accession number E-MTAB-9870 and are freely available. Conflicts of interest D.T. and L.H. are employees of Galmed Pharmaceuticals. S.L.F. is a consultant to Galmed Pharmaceuticals...
AbstractCompetitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase are currently used to treat patients with hypercholesterolaemia. These inhibitors affect not only cholesterol biosynthesis, but also the production of non-steroidal mevalonate derivatives, that are involved in a ...
Abstract We present the clinical, pathological, biochemical, and molecular results on an infant girl with long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency and data on her deceased elder brother for whom this condition was retrospectively diagnosed. Clinical signs were liver enlargement and ...
Abstract Efflux pump (EP)-mediated multidrug resistance (MDR) seems ubiquitous in bacterial infections and neoplastic diseases. The diversity and lack of specificity of these efflux mechanisms raise a great obstacle in developing drugs that modulate efflux pumps. Since developing novel chemotherapeutic dru...
Submission received: 28 September 2023 / Revised: 31 October 2023 / Accepted: 3 November 2023 / Published: 5 November 2023 (This article belongs to the Special Issue Recent Advances in IoT and Cyber/Physical System)Download keyboard_arrow_down Browse Figures Versions Notes Abstract In recent ...
While that is an attractive submission, I would reject it. First, while it is obviously engaged when considering individual items in a bill of costs, CPR 44.3 is ultimately concerned with the total figure to be recoverable from the paying party by way of costs. Secondly, commercial reality ...
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