9 RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook CoA Also found in:Thesaurus,Medical,Financial,Acronyms,Encyclopedia,Wikipedia. CoA abbr. coenzyme A American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harc...
Statins act by competitively binding to the catalytic domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase, HMGCR)8,9and blocking the conversion of HMG-CoA to mevalonate, the rate-limiting step of cholesterol biosynthesis. Notably, sterols and nonsterol isoprenoids derived f...