Yet, more than half of these patients exhibited poor outcomes in the form of prolonged intensive care unit (ICU) stay, residual paresis, and dysphagia [73]. A systematic review of 42 COVID-19 patients with GBS showed a 40.5% ICU admission rate, with one-third of the patients having ...
The ligand exhibited two different binding modes to form a unique binuclear triply bridged Co(III) cationic complex [Co2(1κN2:2κN2-L) (1κN3:2κO1-HL)2](NO3)2 (1). With the Ni(II) precursor, H2L was hydrolyzed to N′,N˝-butane-2,3-diylidenebis (5-methyl-1H-pyrazole-3...
two other mechanistically plausible ways to enhance the SARS-CoV-2-induced RAS imbalance exist. ADAM metallopeptidase domain 17 (ADAM-17) is a TNF-α-converting enzyme. It activates TNF-α by cleaving its extracellular domain, which converts it from its inactive membrane-bound form into its act...
S. 2008. Integration of process-based soil respiration models with whole-ecosystem CO2 measurements. Ecosystems. 11(2): 250-269.Schimel, D. S.: Integration of process-based soil respiration models with whole-ecosystemJ. M. Zobitz,D. J. P. Moore,W. J. Sacks,R. K. Monson,D. R. ...
Recent studies on the pathophysiology of COVID-19 are indicating that the Angiotensin convertase enzyme 2 (ACE-2) and transmembrane serine protease 2 (TMPRSS2) can act as a major component in the fusion of SARS-Cov-2 with target cells. It has also been o
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We detected the membrane-bound form on RASF, which was up-regulated by TNF and even more so by the combination of TNF and IFN-γ. TGF-β regulates many aspects of B cell function from Ig production to apoptosis and an up-regulation on RASF might reduce B cell survival26. In addition ...
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Hypothesis to explain the severe form of COVID-19 in Northern Italy. BMJ Glob Health. 2020;5(6):e002564. 27. Oz M, Lorke DE. Multifunctional angiotensin converting enzyme 2, the SARS-CoV-2 entry receptor, and critical appraisal of its role in acute lung injury". Biomed Pharmacother. ...
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