(EC50) and half-life values were obtained from the literature285,286.e, Lethal mutagenesis caused by molnupiravir, which is converted intracellularly into an active triphosphate form (EIDD-2061) that increases the frequency of G-to-A and C-to-U transition errors within genomic RNA (gRNA)122...
ArticlePubMedGoogle Scholar Dickinson WJ, Potter GG, Hybels CF, McQuoid DR, Steffens DC. Change in stress and social support as predictors of cognitive decline in older adults with and without depression. Int J Geriatr Psychiatry. 2011;26(12):1267–74. ArticlePubMedPubMed CentralGoogle Scholar...
1d). Interestingly, quantitative analysis of our lattice light-sheet microscopy data showed a highly unidirectional formation of the tubules with co-clusters – EphB6:ephrinB1 clusters first form when membrane protrusions of ephrinB1-expressing cells are in contact with EphB6-expressing cells (Fig....
two other mechanistically plausible ways to enhance the SARS-CoV-2-induced RAS imbalance exist. ADAM metallopeptidase domain 17 (ADAM-17) is a TNF-α-converting enzyme. It activates TNF-α by cleaving its extracellular domain, which converts it from its inactive membrane-bound form into its act...
Under the assumption of constitutive co-operation, we find that a co-operative strain is under positive selection whenever bbG;g > c, where b and c are the benefits of co-operation and βG,g is the coefficient of relatedness (in regression coefficient form), a measure of genetic assortment...
Violán C, Foguet-Boreu Q, Fernández-Bertolín S, Guisado-Clavero M, Cabrera-Bean M, Formiga F, et al. Soft clustering using real-world data for the identification of multimorbidity patterns in an elderly population: cross-sectional study in a Mediterranean population. Available from: http:...
The Ewing sarcoma PDX tumor NCH-EWS-1 was obtained from Dr. Peter J. Houghton at UT Health San Antonio. Cell transfection was performed using polyethylenimine (PEI), as described previously16,77. The packaging of lentiviral shRNA or cDNA expressing viruses and subsequent infection of various ...
Results In this report, the most potent clinical PARP inhibitor, talazoparib, is loaded into the core of a polymeric nanoparticle (NP-Tal), which is interfaced with antibody-photosensitizer conjugates (photoimmunoconjugates, PICs) to form PIC-NP-Tal. In parallel, a ...
There were insufficient influenza cases during the pandemic to form a comparator. The index study date was the date of discharge from hospital. We excluded people who died during their index hospitalization, were hospitalized for influenza or sepsis in the 1 year prior to index study date, had ...
ORNs extend their axons to the olfactory bulb to form synapses with mitral cells and tufted cells, the second-order olfactory neurons in the olfactory bulb. These neurons then project their axons through the lateral olfactory tract into the olfactory cortex. Olfactory dysfunction can occur if any...