1. 单药剂量递增研究(Part A) 主要目的:评价不同剂量SIGX1094R在晚期实体瘤(局部晚期或转移性)患者中的安全性和耐受性;通过观察SIGX1094R在爬坡剂量范围内的剂量限制性毒性(DLT),探索最大耐受剂量(MTD),同时为确定II期推荐剂量(RP2D)提供支持。 次要目的:评价在空腹条件下,SIGX1094R单药和其主要代谢产物(M9...
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Author Contributions: Dr Havers had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Concept and design: Havers, Pham, Milucky, Meek, Lynfield, Como-Sabetti, Talbot. Acquisition, analysis, or interpretat...
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Conflict of Interest Disclosures: Dr Bierens reported serving as consulting governor for Koninklijke Maatschappij tot Redding van Drenkelingen (founded 1767). No other disclosures were reported. Additional Contributions: Luis Miguel Pascual Gomez, BS, an International Drowning Researchers’ Alliance–affiliat...
which form the single factor “resilience” (Campbell-Sills and Stein2007). These statements/proposals are answered on a 5-point Likert scale (from 0 = not at all trueto 4 = almost always true). Examples of the statements/proposals are the following: “I tend to bounce back afte...
Our final recommendation is vital and is directed to all scientists, especially behavioural and social, as well as to policy institutions: do not wait until the next crisis to form partnerships. It is always a good time to build relationships between organizations, clinics, schools, governments, ...
Venular ECs form the primary site of leukocyte trafficking from the circulating blood into the tissues. ECs are assumed to participate in leukocytes recruitment from the bloodstream into the sites of infection and inflammation.23During the process of SARS-CoV-2 infection, inflammatory cytokines of IL...
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Structural assembly of novel strain: the SARS-CoV-2 SARS-CoV-2 is a zoonotic virus belonging to the β-coronavirus genus consisting of crown-shaped peplomers, enveloped as positive-single-strand RNA (+ ssRNA) viruses, identified in the pleomorphic form with a size of 80–160 nm and a ...