2020年4月8日，中国科学院上海神经所杨辉及周海波共同通讯在Cell 在线发表题为“Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice”的研究论文。该项研究通过运用最新开发的RNA靶向CRISPR系统CasRx特异性地在视网膜穆勒胶质细胞中敲低Ptbp1基因的表达，首次在成体中实现了...
2020年4月8日,中国科学院上海神经所杨辉及周海波共同通讯在Cell在线发表题为“Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice”的研究论文,该项研究通过运用最新开发的RNA靶向CRISPR系统CasRx特异性地在视网膜穆勒胶质细胞中敲低Ptbp1基因的表达,首次在成体中实现了视神...
【42】2020年4月8日,中国科学院上海神经所杨辉及周海波共同通讯在Cell在线发表题为“Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice”的研究论文,该项研究通过运用最新开发的RNA靶向CRISPR系统CasRx特异性地在视网膜穆勒胶质细胞中敲低Ptbp1基因的表达,首次在成体中实现...
Amphetamine-like stimulants are commonly used to treat sleepiness in narcolepsy. These compounds have little effect on rapid eye movement (REM) sleep-related symptoms such as cataplexy, and antidepressants (monoamine uptake inhibitors) are usually required to treat these symptoms. Although amphetamine-...
DogsHumansRodentiaMalariaPsychoses, Substance-InducedDose-Response Relationship, DrugAdultChildGuidelines as TopicCNS adverse drug events are dramatic, and case reports have influenced clinical opinion on the use of antimalarials. Malaria also causes CNS symptoms, thus establishing causality is difficult.CNS...
Cerebrospinal fluid cytological and biochemical characteristics in the presence of CNS neoplasia. Central nervous system (CNS) infiltration must be ruled out in patients with known neoplastic diseases and neurological symptoms. It was done a retrospecti... Sérgio,M,de,... - 《Arquivos De Neuro Ps...
2020年4月8日,中国科学院上海神经所杨辉及周海波共同通讯在Cell在线发表题为“Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice”的研究论文,该项研究通过运用最新开发的RNA靶向CRISPR系统CasRx特异性地在视网膜穆勒胶质细胞中敲低Ptbp1基因的表达,首次在成体中实现了视...
【42】2020年4月8日,中国科学院上海神经所杨辉及周海波共同通讯在Cell 在线发表题为“Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice”的研究论文,该项研究通过运用最新开发的RNA靶向CRISPR系统CasRx特...
Several CNS transmitters/transmitter systems are known to be involved in micturition control, but few drugs with a defined CNS site of action (e.g. baclofen, imipramine and duloxetine) have been used for the treatment of voiding disorders. GABA, glutamate, opioid, serotonin, noradrenaline (norepin...
The observed patterns of enzyme transport from cerebrospinal fluid to the CNS tissues and the resultant biological activity (a) warrant further investigation of intrathecal delivery of I2S via lumbar catheter as an experimental treatment for the neurological symptoms of Hunter syndrome and (b) may ...