sAPPβ, leading to the decreased Aβ burden, which contributes to the reversal of memory deficits in AD. The present work highlights the crucial role of histone deacetylase inhibitors in alleviating AD-like pathology and supports that ADAM10 could serve as a disease-modifying and therapeutic ...
Distinct alterations of retinal structure between thalamic and extra-thalamic subcortical infarction patients: A cross-sectional and longitudinal study 丘脑和丘脑外皮质下梗死患者视网膜结构的不同改变:一项横断面和纵向研究 We explored the cross-sectional and longitudinal retinal structural thicknesses in SSI pat...
Electroacupuncture pretreatment preserves telomerase reverse transcriptase function and alleviates postoperative cognitive dysfunction by suppressing oxidative stress and neuroinflammation in aged mice 电针预处理通过抑制氧化应激和神经炎症保护端粒酶逆转录酶功能,减轻老年小鼠术后认知功能障碍 ...
(lncRNAs) play critical roles in various physiopathology processes, but existing research on the functions of RVLM lncRNAs on SIH has been lacking. In this study, we investigated the roles of RVLM lncRNAs in SIH. LncRNA INPP5F was a key factor that inhibited SIH progression, and the ...
Circular RNA as biomarkers for acute ischemic stroke: A systematic review and meta-analysis 环状RNA作为急性缺血性卒中生物标志物的系统评价和荟萃分析 This review updated the latest knowledge about the role of circular RNAs in the development of acute ischemic stroke, and discussed the practicability of...
CNS Neuroscience & Therapeutics provides a medium for rapid publication of original clinical, experimental, and translational research papers, timely reviews and reports of novel findings of therapeutic relevance to the central nervous system, as well as papers related to clinical pharmacology, drug devel...
Insulin-like growth factor-2 is a promising candidate for the treatment and prevention of Alzheimer's disease 胰岛素样生长因子-2有望用于阿尔茨海默病的治疗和预防 Insulin-like growth factor 2 (IGF2) is a neurotrophic peptide that is implicated in memory function and declines in Alzheimer's disease...
Our study suggests that oxytocin has anti-anxiety effects and provides novel insights into the role of PVN-CeA oxytocin projections in the regulation of anxiety-like behaviors induced by inflammatory pain. 我们的研究表明,催产素具有抗焦虑作用,并为PVN-CEA催产素投射在炎性疼痛诱导的焦虑样行为调节中的...
Systems genetics analysis reveals the common genetic basis for pain sensitivity and cognitive function 系统遗传学分析揭示了疼痛敏感性和认知功能的共同遗传基础 Pain sensitivity is associated with genetic background and Rnf20-mediated PI3K-Akt signaling may involve in the regulation of pain sensitivity and...
CYP1B1 affects the integrity of the blood–brain barrier and oxidative stress in the striatum: An investigation of manganese-induced neurotoxicity CYP1B1影响纹状体血脑屏障的完整性和氧化应激: 锰诱导的神经毒性的研究 CYP1B1 deficiency disrupts the integrity of the blood–brain barrier and aggravates ma...