"There are clearly many shades of major depression. … There is no 'one-size-fits-all' solution. Rather, the best clinical intervention for the person with [treatment-resistant depression] should be personalized to the individual. A major aim of ongoing research is to improve the ability to ...
Introduction: Ciguatoxin (CTX) is a potent marine toxin known for its detrimental effects on the Central Nervous System (CNS), inducing symptoms of depression and neurological dysfunction. The nervous system's synapses' threshold for opening voltage-gated sodium channels is reduced by ciguatoxin. ...
Senescent cells accumulate throughout the body with advanced age, diseases and chronic conditions. They negatively impact health and function of multiple systems, including the central nervous system (CNS). Therapies that target senescent cells, broadly
Mirtazapine (Remeron®, Zispin®) is a noradrenergic and specific serotonergic antidepressant (NaSSA) that is approved in many counties for use in the treatment of major depression. Monotherapy with mirtazapine 15—45mg/day leads to rapid and sustained improvements in depressive symptoms in patient...
内容简介:In these two back-to-back Nature papers, we unraveled that up-regulated astroglial Kir4.1 in the lateral habenula, the ‘anti-reward center’, enhanced neuronal burst firing to mediate depression-like symptoms. Notably, ketamine, the super-star rapid antidepressant, is able to block ...
the signs and symptoms of PDImprovement in rigidity, tremor, depressionGood functional mobility can be maintained for many years Life expectancy is increased substantiallyHowever,disease progresses and may get worse Treatment with L-Dopa L-dopa therapy can’t block the progresse of PD "buffering" ...
ResultsOf the 236 cases, 40.2% had clinical anxiety (median HADS-A: 6.0), 16.0% had clinical depression (median HADS-D: 3.0), and 41.3% had clinical fatigue (median FSS: 4.56). The co-occurrence of all three symptoms was 3.76 times greater than expectation. Younger age, higher ...
Other emotions exhibit direct influence on the gut, particularly “negative” feelings. People with anxiety and panic disorders frequently report IBS-like symptoms, while slowed transit and constipation often accompany depression.The same stress factors in another person may act on the stomach rather ...
receptor modulators, and in particular the use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with serotonin action, such as in treating Alzheimer's disease, cognition disorders, depression, and ...
Alprazolam is a benzodiazepine derivative that is currently used in the treatment of generalized anxiety, panic attacks with or without agoraphobia, and depression. Alprazolam has a fast onset of symptom relief (within the first week); it is unlikely to produce dependency or abuse. No tolerance to...