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本申请属于动物疾病预控技术领域,具体涉及抑制剂CNI‑1493在猪繁殖与呼吸综合征中应用专利申请事宜。作为eIF5A羟脯氨酸修饰的特异性抑制剂CNI‑1493,将其处理细胞后,用于抑制PRRSV在细胞内的增殖;所述细胞为真核生物细胞。本申请中,发明以MARC‑145细胞为例,在利用eIF5A羟脯氨酸修饰特异性抑制剂CNI‑1493处理细...
在96孔细胞板中培养marc-145细胞,当其长满底面积80%以上时候,分别将0.1μm、1μm、10μm、100μm的cni-1493抑制剂加入板孔中,每个浓度8个重复,并以加入培养基的板孔作为对照。加入抑制剂cni-1493后,将细胞板放入co2培养箱继续培养30min后取出。使用分光光度计测定波长490nm处的吸光值。 结果如图1所示,与...
The tetravalent guanylhydrazone CNI-1493 (CNI-1493) has been shown to inhibit macrophage activation, reduce systemic inflammation as well as proinflammatory cytokine production. Here we report for the first time that CNI-1493 also influences the biology of dendritic cells (DC). In order to become...
To investigate if administration of CNI-1493, an inhibitor of the synthesis of proinflammatory cytokines and NO, protects against development of joint destruction in collagen induced arthritis (CIA) in rats.In a placebo controlled experiment, CNI-1493 was given once daily intraperitoneally after onset...
P1-100: CNI-1493 inhibits Aβ production and prevents plaque formation in an animal model of Alzheimer's disease 来自 Semantic Scholar 喜欢 0 阅读量: 10 作者:Michael Bacher,Richard Dodel,Bayan Aljabari,Kathy Keyvani,Philippe Marambaud,Rakez Kayed,Charles Glabe,Nicole Goertz,Susanne Schnell,...
CNI-1493 is a potent anti-inflammatory agent, which deactivates macrophages and inhibits the synthesis of proinflammatory mediators. The objective of the present study was to identify the role of the central nervous system (CNS) and efferent vagus nerve signaling in CNI-1493-mediated modulation of...
CNI-1493, a newly developed, water-soluble tetravalent guanylhydrazone, is a powerful inhibitor of tumor necrosis factor (TNF) and interleukin-1 (IL-1) synthesis. Microencapsulation of drugs into microcapsules that target macrophages has improved the effectiveness of both TNF and IL-1 neutralizing ...
aImpaired vascular permeability appears to be mediated by macrophages as CNI- 1493, a macrophage pacifant, attenuated increase in vascular 被削弱的血管渗透性看上去由巨噬细胞斡旋, CNI- 1493年,巨噬细胞pacifant,在血管的变稀的增量 [translate] ...
太阳能电池阵列模拟器在太阳能应用领域具有至关重要的地位,其广泛的用途涵盖了光伏系统研发、测试以及教学等多个方面。 (一)多种功能集成一身 太阳能电池阵列模拟器具有恒内阻模式,用户可根据实际需求对内阻进行设定,这为模拟不同的工作场景提供了极大的灵活性。其强大的图形化上位机软件,使得操作更加直观便捷,用户可...