目前,应用gE的GSK重组带状疱疹疫苗已成功上市销售。 HSV-1 gE可以结合IgG Fc结构域,干扰C1结合到抗原-抗体复合物上,抑制抗体依赖的细胞介导的细胞毒作用(ADCC)。HSV-1 gC可以结合补体系统中的C3b,干扰C5和P蛋白与C3b结合的过程,加速旁路途径中C3转化酶的降解。因此这些表达病毒颗粒表面或者感染宿主细胞表面的免疫...
When compared in an in vitro human innate immunity construct to AS01B, the QS21/MPL liposomal adjuvant system of GSK, and with QS21-Liposomes used as benchmarks, SPA14 displayed the strongest immunostimulatory potential based on antigen-presenting cell (APC) activation and cytokine secretion, ...
Glycoprotein B (gB), the herpesvirus fusion protein, is a target for neutralizing antibodies and a vaccine candidate due to its indispensable role in infection. Here we show the crystal structure of the HCMV gB ectodomain bound to the Fab fragment of 1G2, a neutralizing human monoclonal ...
adjuvants;alpha-tocopherol;nanoemulsions;vaccine delivery;self-emulsification 1. Introduction Emulsion adjuvants are well-established as safe and effective when combined with a variety of antigens, particularly influenza vaccines for both seasonal and pandemic responses [1,2,3]. Given their ability to ...