3.Arber DA, Orazi A, Hasserjian R, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127(20):2391-2405. 4.Shen Q, Ouyang J, Tang G, et al. Flow cyto...
3.Arber DA, Orazi A, Hasserjian R, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127(20):2391-2405. 4.Shen Q, Ouyang J, Tang G, et al. Flow cytometry immunophenotypic findings in chronic myelomonocytic leukemi...
研究发现,LILRB4抗体可以阻断LILRB4靶点,增强T细胞对肿瘤细胞的杀伤作用,可减少白血病细胞向骨髓、肝脏以及脑渗透,延长生命。简而言之,LILRB4改变了免疫抑制的微环境,从而抑制T细胞的活性,导致出现逃逸现象,并出现肿瘤细胞的增殖转移等不良后果。 以明生物联合德克萨斯大学在《自然》杂志上发表了原创性研究,阐明LILRB4在AM...
4.Anami Y , Deng M ,Gui X , et al. LILRB4-Targeting Antibody-Drug Conjugates for the Treatment of Acute Myeloid Leukemia. 2020.
Leukemic infiltrate in the skin is commonly seen in patients with acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) but is rarely seen in patients with CMML. Leukemia cutis in a patient with CMML is believed to be a predictor of disease progression to acute leukemia. As such,...
慢性髓单粒细胞性白血病(CMML)合并Sweet综合征起病急骤,临床少见,救治困难,预后较差.现将本院收治1例报告如下.患者男性,52岁.2002年9月中旬出现无诱因发热,体温最高39.3℃.两天后面部,颈部,双胫前及手背先后出现疼痛性红斑,门诊予甲泼尼龙(甲基强松龙)40 mg/d,静滴3天,体温恢复正常,皮疹消退.一周后再次出现...
(also known as ILT3), in Phase 1b clinical development for the treatment of acute myeloid leukemia (AML), and chronic myelomonocytic leukemia (CMML). IO-202 has the potential to be the best-in-class antibody therapy for lupus and can extend to other indications in immunology and ...
Specific scoring systems to predict survival of patients with high-risk myelodysplastic syndrome (MDS) and de novo acute myeloid leukemia (AML) after intensive antileukemic treatment based on results of the EORTC-GIMEMA AML-10 and intergroup CRIANT studies Ann Hematol, 94 (1) (2015), pp. 23-...
Myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML) are chronic myeloid clonal neoplasms. To date, the only potentially curative therapy for these disorders remains allogeneic hematopoietic progenitor cell transplantation (HCT), although patient eligibility is limited due to high morbi...
1、Arber DA, Orazi A, Hasserjian R, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016. 127(20): 2391-405. 2、张颖, 谭倩, 曹鹏飞, 陈聪, 陈伟. 单核细胞显著增加 的...