CMML is a rare form of leukemia characterized by high levels of monocytes in the blood. The main symptoms are abdominal pain and feeling full too soon while eating. It is not clear what causes CMML but it can occur after treatments for other cancers. The only cure for CMML is a stem ce...
( 1993 ) Chronic myelomonocytic leukemia (CMML): a myelodysplastic or myeloproliferative syndrome Leukemia and Lymphoma , 9 , 35 – 41 .Michaux JL, Martiat P (1993) Chronic myelomonocytic leukaemia (CMML)—a myelodysplastic or myeloproliferative syndrome? Leuk Lymphoma 9:35–41...
Patients with therapy-related MDS or AML, relapsed/refractory AML, clinical symptoms of central nervous system leukemia, or impaired cardiac function were excluded. Additionally, patients who had received prior treatment with a DACi, AZA or decitabine, or who were currently receiving a drug known ...
Characterized by bone marrow dysplasia and peripheral blood monocytosis, chronic myelomonocytic leukemia (CMML) is one of the most aggressive chronic leukemias and has a propensity for progression to acute myeloid leukemia (AML). Patients with newly diagnosed AML generally present with symptoms related ...
CHRONIC leukemiaMORPHOLOGYMYELODYSPLASTIC syndromesSYMPTOMSOLD ageCMML is a rare clonal myeloid neoplasm belonging to the myelodysplastic syndrome (MDS)/myeloproliferative neoplasm (MPN) group characterized by persistent peripheral blood monocytosis. It is commonly seen in old age and has a varied clinical ...
This review describes important studies concerning animal models of CMML, examples of methodological approaches, and the obtained hematologic phenotypes. Keywords: chronic myelomonocytic leukemia; CMML; mouse models 1. Introduction CMML is a clonal neoplastic hematopoietic stem cell disorder, characterized by...