416 Chronic myelomonocytic leukemia (CMML) is characterized by monocyte/monoblast proliferation, dysplastic features, progression to leukemia and poor prognosis. With the exception of rare cases of CMML with balanced PDGFRa or PDGFRb translocations, the molecular pathogenesis of the majority of CMML ...
chronic myeloid leukemia (CML), whereASXL1mutations are frequent (80%) and splicing mutations are less common (30%)13. However, atypical CML is not associated with monocytosis, and given the fact that in CMML biallelicTET2orTET2/SRSF2co-mutations skew hematopoiesis toward monocytosis, the etiol...
Chronic myelomonocytic leukemia. The 2008 WHO classification distinguishes 2 different types of CMML based on percentage of blasts and promonocytes in peripheral blood (PB) and BM.43 The panel agreed to use the CMML-specific scoring system (CPSS)44 for the recommendation of HSCT for CMML patients...
Outcomes of Patients (pts) with Myelodysplatic Syndrome (MDS) and Chronic Myelomonocytic Leukemia (CMML) Post Clofarabine Failure Background and aims : Prognosis in pts with MDS post decitabine failure is reported to be poor, but there are no published data pertaining to survival, par... H Gh...
PrognosisMyeloproliferative disordersMyelodysplastic syndromesThe FAB group proposed to distinguish two subgroups of chronic myelomonocytic leukemia (CMML). Depending on the total leukocyte count, a myelodysplastic type (MDS-CMML) ( 13,000 microl(-1)). Based on retrospective analyses of 158 p...
prognosis; to a composition for treating such a specific CMML; to a method for diagnosing a chronic myelomonocytic leukemia (CMML) associated with an increased level of immunosuppressive CD14-/CD24+/CD15+ cells in a subject, which comprises the steps of (i) determining the level of expression...
CHRONIC MYELOMONOCYTIC LEUKEMIAWORLD-HEALTH-ORGANIZATIONGENE-MUTATIONSPROPOSALSASXL1Recently a new three-group clinical classification was reported by an International Consortium to stratify CMML patients with regard to prognosis. The groups were defined as follows: (1) Myelodysplastic (MD)-CMML: WBC≤10...
Patients with t-CMML have a poor prognosis and should be considered for investigational treatment.Subari, SalihPatnaik, MrinalAlfakara, DimaGangat, NaseemaElliott, MichelleHogan, WilliamLitzow, MarkAl-Kali, ArefClinical lymphoma, myeloma & leukemia...
We found that oncogenic NRAS rapidly and efficiently induced chronic myelomonocytic leukemia (CMML)- or acute myeloid leukemia (AML)- like disease in mice, indicating that mutated NRAS can function as an initiating oncogene in the induction of myeloid malignancies. In addition to CMML and AML, we...
PrognosisMyeloproliferative disordersMyelodysplastic syndromesThe FAB group proposed to distinguish two subgroups of chronic myelomonocytic leukemia (CMML). Depending on the total leukocyte count, a myelodysplastic type (MDS-CMML) ( 13,000 microl(-1)). Based on retrospective analyses of 158 patients ...