Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia. Blood 94, 2056–2064 (1999). CAS PubMed Google Scholar Ishikawa, F. et al. Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region. Nat. ...
1、Arber DA, Orazi A, Hasserjian R, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016. 127(20): 2391-405. 2、张颖, 谭倩, 曹鹏飞, 陈聪, 陈伟. 单核细胞显著增加 的...
成人慢性粒细胞白血病(CML/慢粒) 慢性髓细胞白血病( chronice myelogenous leukemia,CML)是一种起源于造血干细胞的恶性增殖性疾病。病变细胞以携带Ph染色体为特点,在DNA水平表现为9号染色体上ABLI基因与22号染色体上BCR基因断裂重排形成BCR-ABLI融合基因。此融合基因所表达的异常升高的ABLI酪氨酸激酶(tyrosine kinase ,...
Q. I'd like to know how to differentiate between acute leukemia and blast crisis of CML. A. Great question! To diagnose blast crisis (or blast phase) in chronic myeloid leukemia, you need to have one of the following: More than 20% blasts in the blood or
分析结果显示,aCML具有诸多不良特征,以及不良的总生存结果(12.4 vs. 21.8个月,P=0.004)和不良的无AML生存结果(11.2 vs. 18.9 个月,P =0.003)。aCML的特征为白细胞增多和血液中出现髓系前体细胞,而非粒细胞生成异常,是独立的不良预测因子。其他因子(如乳酸脱氢酶、血液中出现原始粒细胞、血小板和细胞遗传学)可...
and Haveman, K.: 1993, ‘Increased risk of acute myelogenous leukemia (AML) and chronic myelogenous leukemia (CML) in a county of Hesse (Germany)’, Soz.-Praeventivmed. 38 , 190-195.Kolb, G., Becker, N., Scheller, S., Zugmaier, G., Pralle, H., Wahrendorf, J. and Havemann,...
随着酪氨酸激酶抑制剂(TKI)的应用,慢性粒细胞白血病(CML)的疗效已显著改善,而对于CML急变期(CML-BP)患者,预后仍然很差,治疗选择也非常有限。儿童和青少年CML-BP的治疗策略很大程度上已经基于成人CML-BP和儿童急性髓系白血病(AML)的治...
Some of these alterations have never been reported in patients and are likely to be clinically irrelevant, as they may be neutral or even reduce the growth advantage of the clone, but mutations known to be associated 1979 Leukemia Chronic myeloproliferative disorders compared NCP Cross et al 1980...
The mutation was frequent in polycythemia vera (PV) (86%) and myelofibrosis (95%) but less prevalent in acute myeloid leukemia (AML) with an antecedent PV or myelofibrosis (5 [36%] of 14 patients). JAK2 mutation was also detected in 3 (19%) of 16 patients with Philadelphia-chromosome ...
proliferation of myeloblasts and immature progenitor cells, aspects of the disease clinically appear to mimic AML more so than CML-CP. Thus, the use of an acute leukemia chemotherapeutic regimen + TKI may be efficacious by affecting multiple cell survival/death mechanisms rather than one ...