Description: CML, Human, mAb CML26 The monoclonal antibody CML26 recognizes human CML (carboxymethyl-lysine). CML is known to be formed from the oxidation of both carbohydrates and lipids. This makes CML- a biomarker of general oxidative stress. Carboxy
Chronic myelocytic leukemia (CML) is a pluripotent stem cell disease characterized by the presence of the Philadelphia (Ph) chromosome in the leukemic cells of 96% of all CML patients. The Ph chromosome is the result of a translocation between chromosomes 22 and 9. The human c- abl oncogene...
Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia. Blood 94, 2056–2064 (1999). CAS PubMed Google Scholar Ishikawa, F. et al. Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region. Nat. ...
Standardized monitoring of BCR::ABL1 mRNA levels is essential for the management of chronic myeloid leukemia (CML) patients. From 2016 to 2021 the European Treatment and Outcome Study for CML (EUTOS) explored the use of secondary, lyophilized cell-based
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One of 2 epitopes, the epitope of CML66; aa70–78: WIQDSVYYI generated the epitope-specific CTL, in vitro, and those CTL exerted anti-leukemia activity against human myeloid leukemia cell line cells in an HLA-A*2402-restricted fashion, but not any cytotoxicity against normal cells. Further...
This is a preview of subscription content, log in via an institution to check access. References Nowell PC, Hungerford DA (1960) A minute chromosome in human granulocytic leukemia. Science 132: 1497 Google Scholar Rowley JD (1973) A new consistent chromosomal abnormality in chronic myelogenous...
Regional Analysis Technological Advancements to Aid the Market in North America North America is home to some of the biggest telecom companies such as Motorola and Verizon. Investments made by these companies in R&D to create advanced telecommunications solutions are expected to enable the region to ...
Description: The GW4CML3 monoclonal antibody reacts with human and mouse interferon regulatory factor 8 (IRF8; ICSBP). IRF8 is a 50 kDa transcription factor that plays a critical role in the development of dendritic cells (DC). Specifically, IRF8 is essential in the development and differenti...
No lymphocytosis associated with the proliferation of clonal CTLs or NK cells12 was observed in dasatinib treated patients. The study was approved by the institutional Human Research Ethics Committee and conducted in accordance with the Declaration of Helsinki. PB mononucleated cells (PBMCs) from ...