Determining the role of CMKLR1 in effector T cell activation and migration may provide insights into local molecular mechanisms controlling lymphocyte function and fate within the CNS during WNV.Alejandro CortesDouglas DurrantThe Journal of Immunology...
were used in function and mechanism study. Mouse models of extrahepatic and intrahepatic metastasis were employed to evaluate the therapeutic potential of chemerin. RESULTS: Chemerin expression was significantly downregulated in hepatocellular carcinoma, and associated with poor prognosis of HCC patients. ...
Function:Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional ef...
(NLRP3) were significantly lower in the KCs and mice treated with Wortmannin than the KCs treated with Chemerin only and mice fed with high fat diet only.In addition,changes in mouse weight,hepatic steatosis,liver function,insulin resistance and glucose tolerance were much milder in mice treated...
Processing, signaling, and physiological function of chemerin International Union of Biochemistry and Molecular Biology Life, 66 (2014), pp. 19-26 CrossrefView in ScopusGoogle Scholar Meder, et al. 2003 W Meder, M Wendland, A Busmann, C Kutzleb, N Spodsberg, H John, R Richter, D Schle...
[4]Tumor-derived CD4+CD25+regulatory T cell suppression of dendritic cell function involves TGF-βand IL-10[J].Nicolas Larmonier,Marilyn Marron,Yi Zeng,Jessica Cantrell,Angela Romanoski,Marjan Sepassi,Sylvia Thompson,Xinchun Chen,Samita Andreansky,Emmanuel Katsanis.Cancer Immunology,Immunotherapy.2006...
In conclusion, CMKLR1 gene deletion attenuates the effects of chronic DHT treatment on ovarian function in experimental PCOS, likely via BMP4 signaling.doi:10.1038/SREP21328Mi TangChen HuangYu-Fei WangPei-Gen RenLi ChenTian-Xia XiaoBao-Bei Wang...
Chemerin is an adipokine with an established role in immunity, adipose tissue function and metabolism, acting in autocrine, paracrine and endocrine manners. We investigated the protein expression of chemerin and its receptor, CMKLR1, in human aortas, coronary vessels and the respective periadventitial...
The mRNA of this receptor is expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow, and fetal liver. Using fluorescence in situ hybridization the gene encoding CMLKR1 (chemokine-like receptor 1) was ...