However, another form of TACI exists wherein the N-terminal CRD is removed by alternative splicing. We find that this shorter form is capable of ligand-induced cell signaling and that the second CRD alone (TACI_d2) contains full affinity for both ligands. Furthermore, we report the solution...
Full size image The top five OR-gate CAR-T-cell lines based on target-cell lysis and T-cell proliferation (Fig. 2b, marked by arrows) were subjected to repeated antigen challenge to evaluate their propensity for exhaustion. CAR-T cells were challenged with BCMA+/CS1+ K562 cells in the ...
As recalled in Section 5.1, the nature, extent and potential implications of phase transformations in the mantle are far from a full under- standing and still a matter of ongoing research (e.g., [126,155,171–173]). Softening mecha- nisms associated with phase transitions of upper mantle ...