their interactions are mediated through theirconnections to interference units on the other side of the graph. Examples of this type of interference arecommon in marketplaces and two-sided platforms. The cluster-randomized design is a popular method to mitigateinterference when the graph is known, ...
Leveraging Contact Network Structure for Cluster Randomized Trial DesignStep 1: Simulate an undirected, individual-level contact network for a multiple cluster setting; hold mean contact number constant, but vary within- & between-cluster contactsGuy Harling...
Statistical methods Randomization To optimize compliance and generalizability, a cluster- randomized design will be utilized. All participants working in the same clinical unit will be assigned to wear the same respiratory protective equipment (i.e., an N95 or MM) during patient interactions for the...
ter randomized trial design and analysis. For general treatments of multilevel model analysis, see [26, 57]. This chapter is organized into three sections: randomization, analysis, and sample size and power. R code to implement methods is provided. Due to space constraints, we confine our ...
Design pattern and step length The steps in an SWD mark the periods when clusters sequentially cross over unidirectionally from control to intervention, resulting in 2 “stepped wedges” of treatment allocation (Figure 1). Outcomes are measured at baseline before intervention and at each crossover ...
This transition-to-scale trial uses a stepped wedge cluster-randomized design with three steps to evaluate the impact of the LEAPS program on children’s school readiness and female youth development in 99 clusters. A cluster-randomized approach was selected as the point of intervention will be at...
A stepped wedge design [13] is a type of crossover design in which different clusters cross over (switch treatments) at different time points. In addition, the clusters cross over in one direction only—typically, from control to intervention. The first time point usually corresponds to a base...
. Funding sources had no role in study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the article for publication. Author information Author notes Deceased: Monther Bajbouj. Deceased: Meinhard Classen. These authors ...
Impact of salt substitute and stepwise reduction of salt supply on blood pressure in residents in senior residential facilities: design and rationale of the DECIDE-Salt trial. Am. Heart J. 226, 198–205 (2020). Article PubMed Google Scholar Institute of Medicine. Sodium Intake in Populations:...
The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.