Sample size estimationAnalysisScientists often use randomized controlled trials to compare a newly developed treatment to the existing one, or to a placebo. Patients are randomly assigned to a treatment, and they are compared with respect to the outcome of interest. The cluster randomized trial (...
A sample size calculator is presented for calculating appropriate sample sizes for cluster trials, whilst allowing the implications of both methods of inflation to be considered. 展开 关键词: Cluster randomized trial Sample size Calculator Inflation factor ...
RCT: sample size formulae under individual randomisation Following standard formulae, for a trial using individual randomisation[14], for fixed power (1 - β) and fixed sample size (n) per arm, the detectable difference, d I , with variance var(d I ) = 2σ 2 /n I is: (1) where...
Sample size calculations for stepped wedge and cluster randomised trials: a unified approach To clarify and illustrate sample size calculations for the cross-sectional stepped wedge cluster randomized trial (SW-CRT) and to present a simple approach... K Hemming,M Taljaard - 《Journal of Clinical ...
The stepped-wedge cluster randomized design has been increasingly employed by pragmatic trials in health services research. In this study, based on the GEE approach, we present closed-form sample size calculation that is applicable to both closed-cohort and cross-sectional stepped wedge trials. Impor...
A simplified sample size calculation for a cluster randomized crossover trial with a binary survival outcome (the " T-BOSS " method) was compared to the cl... E Case 被引量: 0发表: 2014年 Correction. 'Sample size calculation for cluster randomized cross-over trials' by Giraudeau B, Ravau...
Background: Cluster randomized trials (CRTs) are a popular trial design. In most CRTs, researchers assume equal cluster sizes when calculating sample sizes. When clusters vary, assuming equal sized clusters may result in low study power. There are two common approaches to sample size calculations ...
1.Sample size determination through power simulation; practical lessons from a stepped wedge cluster randomised trial (SW CRT) and spring 机译:通过功效模拟确定样本量;逐步楔形聚类随机试验(SW CRT)的实际课程 Munyaradzi Dimairo ,Mike Bradburn ,Stephen J Walters - Trials - 2011 2.Sample size det...
performed in accordance with standard criteria for a cRCT [16,19,22,27]. The sample size was adjusted using an inflation factor of 1.43 to account for cluster randomization: seven clusters per trial arm, with a cluster size of thirty-four patients and an intra-cluster correlation coefficient ...
The cluster randomized crossover (CRXO) design is gaining popularity in trial settings where individual randomization or parallel group cluster randomizati... Sarah,J,Arnup,... - 《Systematic Reviews》 被引量: 15发表: 2014年 Sample Size Calculations for Clinical Trials Introdution General Principl...