Cluster randomised trials: Time for improvement. the implications of adopting a cluster design are still largely being ignored. BMJ. 1998;317:1171-2. 48. Berta W LA, Valdmanis V. . Observations on institutional long-term care in ontario: 1996- 2002. Can J Aging 2005:70-84.Campbell MK, ...
A cluster randomised trial (CRT) isa randomised controlled trial in which pre-existing groups, called clusters, of individuals are randomly allocated to treatment arms. For example, clusters may be clinical practices or schools where the individuals are patients and school children, respectively. Sandr...
In a randomized clinical or field trial, when randomization units are comprised of groups of individuals, many aspects of design and analysis differ greatly from those of an individually randomized trial. In this chapter, we highlight those features which differ the most, explaining the nature of ...
In a cluster randomised crossover (CRXO) design, a sequence of interventions is assigned to a group, or 'cluster' of individuals. Each cluster receives each intervention in a separate period of time, forming 'cluster-periods'. Sample size calculations for CRXO trials need to account for both...
These data enable sample sizes to be estimated for cluster randomised trials into a range of maternal and child health outcomes. Using such a design, approximately 40 practices would be sufficient to evaluate the effect of an intervention on maternal depression, sleeping, and behavioural problems, ...
How cluster trials are often used to prevent such contamination between intervention and control groups; Comparison of size between cluster trials and individually randomized trials; Suggestion that problems of contamination can often be overcome by increasing the sample size.Diana Elbourne...
The stepped wedge cluster randomised trial: Rationale, design, analysis, and reporting 2015, BMJ (Online) An introduction to implementation science for the non-specialist 2015, BMC Psychology Risk prediction models: II. External validation, model updating, and impact assessment 2012, Heart The stepped...
\"Risk Watch\": Cluster randomised controlled trial evaluating an injury prevention program Objective: to evaluate the effectiveness of a school-based injury prevention program. Design: Cluster randomised controlled trial. Setting: 20 primary sc... D Kendrick,L Groom,J Stewart,... - 《Inj Prev...
BackgroundMany previous reviews of cluster randomised trials have been critical of the quality of the trialsreviewed, but none has explored determinants of the quality of these trials in a specific field over anextended period of time. Recent work suggests that correct conduct and reporting of thes...
Cluster Randomised Trials, Second Editionthoroughly describes the aspects of CRT designs and the analysis of data from such trials. After presenting some basic concepts, Hayes and Moulton focus on the clustering aspect of the design. They cover between- and within-cluster variability and correlation,...