In the low-GC, Gram-positive model organism Bacillus subtilis, the AAA+ protein ClpC requires specific adaptor proteins not only for substrate recognition but also for chaperone activity. The McsB adaptor is activated particularly during heat stress, allowing the controlled degradation of the CtsR ...
trans-Acting Arginine Residues in the AAA+ Chaperone ClpB Allosterically Regulate the Activity through Inter- and Intradomain Communication. The molecular chaperone ClpB/Hsp104, a member of the AAA+ superfamily (ATPases associated with various cellular activities), rescues proteins from the aggr... ...
The heat-inducible CtsR regulon of Bacillus subtilis codes for three Clp proteins with chaperone or protease activity. While the importance of ClpC and Clp... M Miethke,M Hecker,U Gerth - 《Journal of Bacteriology》 被引量: 132发表: 2006年 ctsR of Lactococcus lactis encodes a negative regula...
ClpC in Synechococcus elongatus has been noted to possess ATPase activity as well as function as a molecular chaperone without the need of additional chaperones or adaptor proteins [52]. It is suggested that ClpC functions in part as a housekeeping chaperone in vivo, protecting unfolded, newly ...
ClpC is an Hsp100/Clp protein, an ATP-dependent chaperone that belongs to the AAA+ protein family. ClpC can form an ATP-dependent protease by associating with the peptidase ClpP. Deletion of clpC causes L. monocytogenes to be highly vulnerable to multiple stresses, such as iron starvation,...
The regulation of NblA expression would be an effective method to control the activity of a particular Clp protease quickly, without affecting its other activities (51). Proteins binding to the Clp/HSP100 chaperone partner of a Clp protease to modulate substrate recognition are called adaptor ...
Quantitative analysis of the chloroplast molecular chaperone ClpC/Hsp93 in Arabidopsis reveals new insights into its localization, interaction with the Clp proteolytic core, and functional importance. J Biol Chem 2014;289:11318-30.L.L. Sjogren, N. Tanabe, P. Lymperopoulos, N.Z. Khan, S.R....
CtsR, a novel regulator of stress and heat shock response, controls clp and molecular chaperone gene expression in gram-positive bacteria. clpP and clpC of Bacillus subtilis encode subunits of the Clp ATP-dependent protease and are required for stress survival, including growth at high tempera.....