(A) Structures of natural cyclomarin A (CymA) and derived compounds used in this study. The colors represent the residue positions where the natural compound has been changed.19,26,46 (B) Structure of ecumicin and its derivatives used in this study. The colors represent the residue positions...
Crystal structures reveal that PaClpP2 has non‐canonical features in its N‐ and C‐terminal regions that explain its poor interaction with unfoldases. However, experiments in vivo indicate that the PaClpP2 peptidase active site uniquely contributes to biofilm development. These data strongly...
interrogans share a low sequence identity (∼40%), their tertiary structures are very similar. A structural comparison of the ClpP1 and the ClpP2 subunits of the Mycobacterium and the Leptospira reveal that they are quite analogous with an average root mean square deviation (rmsd) of ∼0.6...
Comparison with available crystal structures of ClpP and ClpX in different states allows us to understand important aspects of the complex mode of action of ClpXP and provides a structural framework for future pharmacological applications.This is a preview of subscription content, access via your ...
We have also pledged to revisit and strengthen our decarbonisation targets at least every five years as technologies advance and cost structures change, while tracking our progress against the goals of the Paris Agreement. Our pledges can also be seen in another context. We have been investing...
et al., 2009). Following crystallization, structures for ClpT1 and ClpT2 were determined and compared with structural features to N-domains of bacterial Clp chaperones; the in vivo signifi- cance of two domains was tested. A functional model for ...
* the command line arguments to parse and the Clp_Option structures. * A loop repeatedly calls Clp_Next() to parse the arguments. * * * Unlike many command line parsing libraries, CLP steps through all arguments * one at a time, rather than slurping up all options at once. This makes...
Clp protease complexes from photosynthetic and non-photosynthetic plastids and mitochondria of plants, their predicted 3-D structures and functional implic... The present study examines the application of Resource Dependence Theory and... J Plane - HRM in tourism and hospitality: international perspectiv...
Clp proteases play a central role in bacterial physiology and, for some bacterial species, are even essential for survival. Also due to their conservation among bacteria including important human pathogens, Clp proteases have recently attracted considera
Bacterial CIpB and its eukaryotic homolog Hsp104 are essential proteins of the heat-shock response, form large ring-like structures, and belong to the Hsp100 family of ATPases associated with diverse cellular activities (AAA+). Unlike any other chaperone, including other members of the Hsp100 ...