medications.[1] In those with schizophrenia and schizoaffective disorder it may decrease the rate of suicidal behavior.[1] It is more effective than typical antipsychotics, particularly in those who are treatment-resistant.[4][5][6] It is used by mouth,[1] or by injection into a muscle....
The typical recommended dosing range is 300 mg to 450 mg total daily, split into smaller doses and taken throughout the day. The maximum total daily dose is 900 mg. Interactions between Clozapine (Clozaril) and other drugs Clozapine (Clozaril) may interact with certain medications or ...
Dose adjustments may be necessary in patients with concomitant use of: strong CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin, or enoxacin); moderate or weak CYP1A2 inhibitors (e.g., oral contraceptives, or caffeine); CYP2D6 or CYP3A4 inhibitors (e.g., cimetidine, escitalopram, erythro...
Dose adjustments may be necessary in patients with concomitant use of: strong CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin, or enoxacin); moderate or weak CYP1A2 inhibitors (e.g., oral contraceptives, or caffeine); CYP2D6 or CYP3A4 inhibitors (e.g., cimetidine, escitalopram, erythro...