Case presentation A 64-year-old Caucasian woman known for schizophrenia was brought to the emergency department (ED) with severe signs and symptoms of clozapine intoxication (general deterioration, drowsiness, neutropenia, and ileus). She was on clozapine 700 mg daily amongst other medications. The ...
Clozapine, an antipsychotic agent with relatively weak central antidopaminergic activity, displays atypical pharmacological and clinical properties vis-a-vis the classic antipsychotics. Thus, clozapine is effective against both the positive and negative symptoms of schizophrenia and has a low propensity to ...
Blood Clot.Clozapine may cause a blood clot in the lungs (pulmonary embolism) or veins (deep vein thrombosis). Stop taking clozapine and get emergency help if you have any of the following signs of a blood clot. Chest pain or pressure ...
Therefore, reassess bowel function frequently with careful attention to any changes in the frequency or character of bowel movements, as well as signs and symptoms of complications of hypomotility (e.g., nausea, vomiting, abdominal distension, abdominal pain). If constipation or gastrointestinal hypo...
MANAGEMENT: Close monitoring for signs and symptoms of additive anticholinergic effects such as gastrointestinal hypomotility is advised when clozapine is used with other drugs that have anticholinergic properties, particularly in the elderly and those with underlying organic brain disease, who tend to be...
The coroner expressed concern over the possibility of suicide, but the authors of the report suspected that suicide was very unlikely, since there were no overt signs of toxicity and the staff reported no change in behavior. Pregnancy All antipsychotic drugs cross the placenta and reach the fetus...
Clozapine has shown signs of effectiveness in treating symptoms of schizoaffective disorder, although little research has been carried out to specifically assess this question. The objective of this current work was to analyse the mood-stabilising effectiveness and tolerability of clozapine in patients ...
After entering the body, pathogenic bacteria move to the regional lymph nodes. There they multiply and then enter the bloodstream, releasing toxins and leading to the first signs of the disease. The International Classification of Diseases (ICD-10) classifies brucellosis depending on the type of pa...
None of the subjects had obvious signs of clozap- ine poisoning or significant adverse drug reactions. The patients were instructed to take clozapine orally starting with a small dose; the initial dose was 25 mg/time, 2–3 times a day, and gradually increased to the conventional ...
as well as signs and symptoms of complications of hypomotility (e.g., nausea, vomiting, abdominal distension, abdominal pain). If constipation or gastrointestinal hypomotility are identified, monitor closely and treat promptly with appropriate laxatives, as necessary, to prevent severe complications. ...