particularly with rapid dose-escalation. These reactions can occur with the first dose, at doses as low as 12.5 mg. These reactions can be fatal. The syndrome is consistent with neurally mediated reflex bradycardia (NMRB).
While clozapine has been shown to have superior antipsychotic efficacy without the standard extrapyramidal side effects, it also has some potentially fatal side effects. The unpredictability in client response poses a number of issues for nursing, which has an essential role in assuring that treatment...
particularly with rapid dose-escalation. These reactions can occur with the first dose, at doses as low as 12.5 mg. These reactions can be fatal. The syndrome is consistent with neurally mediated reflex bradycardia (NMRB).
A rare, but frequently fatal, side effect of the antipsychotic drug clozapine is myocarditis. We report a case of hypersensitivity myocarditis secondary to... Maurizio,Pieroni,Roberto,... - 《Chest》 被引量: 48发表: 2004年 Clozapine-induced myocarditis, a widely overlooked adverse reaction Object...
Background: Lipid accretion is one of the major side effects of clozapine pharmacotherapy of schizophrenia that made clozapine into an interesting obesity drug model. Method: Ingenuity Pathway Analysis (IPA) engine was used for core analysis and building the networks of weight regulation. Results: Th...
Severe neutropenia, ANC less than (<) 500/µL, occurs in a small percentage of patients taking clozapine orally disintegrating tablets and is associated with an increase in the risk of serious and potentially fatal infections. Risk of neutropenia appears greatest during the first 18 weeks on tr...
Many minor though some serious and potentially fatal: the more common include constipation, drooling, muscle stiffness, sedation, tremors, orthostasis, hyperglycemia, and weight gain. Extrapyramidal symptoms may subside somewhat after a person switches from another antipsychotic to clozapine. Clozapine (...
clinical efficacy. The concomitant administration of drugs metabolised by or inhibiting cytochrome P450 enzymes may result in altered plasma concentrations of clozapine and subsequent adverse effects. Plasma clozapine concentrations may also be altered by coadministration of drugs which are highly protein-...
Neuroleptic malignant syndrome(NMS) is rare but a potentially fatal side effect of antipsychotics. It is characterized by muscular rigidity, fever, autonomic instability, and altered consciousness. Because it may be a possible result of a precipitous reduction in dopamine receptor activation, the introd...
Nonfatal suicidal intoxication by clozapine. Analyzes a case of survival from clozapine intoxication. Focus on the case of a 23-year-old woman from China, who intended suicide by its overdose, but rec... Ishii,Akira,Mizoguchi,... - Journal of Toxicology -- Clinical Toxicology 被引量: 14发...